Results 21 to 30 of about 1,854,852 (401)

Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation

Cellular & Molecular Biology Letters, 2022
Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident transmembrane protein gene family, and were found to be involved in lipid droplet (LD) formation. Recently,
Gaiping Wang, Anqi Chen, Yu Wu, Danlin Wang, Cuifang Chang, Guoying Yu   +5 more
doaj   +1 more source

Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts

European Respiratory Journal, 2022
Background Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic pulmonary fibrosis (IPF). Senescence and insufficient mitophagy in fibroblasts contribute to their differentiation into myofibroblasts, thereby promoting the development ...
Ruijuan Guan, Liang Yuan, Jingpei Li, Jian Wang, Ziying Li, Z. Cai, Hua Guo, Yaowei Fang, Ran Lin, Wei Liu, Lan Wang, Q. Zheng, Jingyi Xu, You Zhou, Jing Qian, Mingjing Ding, Jieping Luo, Yuanyuan Li, Kai Yang, Dejun Sun, H. Yao, Jianxing He, Wenju Lu   +22 more
semanticscholar   +1 more source

Pulmonary Fibrosis [PDF]

, 2005
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease limited to the lungs and associated with the histologic appearance of usual interstitial pneumonia (UIP) on surgical lung biopsy. The estimated prevalence in the United States is between 35,000 and 55,000 cases,and evidence suggests that the prevalence is increasing for IPF.
Zisman, David A., Keane, Michael P., Belperio, John A., Strieter, Robert M., Lynch, Joseph P.   +4 more
openaire   +2 more sources

Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis

Frontiers in Immunology, 2021
This mini-review summarizes the current evidence for the role of macrophage activation and polarization in inflammation and immune response pertinent to interstitial lung disease, specifically pulmonary fibrosis. In the fibrosing lung, the production and
A. Kishore, M. Petrek
semanticscholar   +1 more source

Advances in the management of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis

British medical journal, 2022
Similarly to idiopathic pulmonary fibrosis (IPF), other interstitial lung diseases can develop progressive pulmonary fibrosis (PPF) characterized by declining lung function, a poor response to immunomodulatory therapies, and early mortality.
Gabrielle Y. Liu, G. S. Budinger, J. Dematte   +2 more
semanticscholar   +1 more source

Pirfenidone and post-Covid-19 pulmonary fibrosis: invoked again for realistic goals

InflammoPharmacology, 2022
Pirfenidone (PFN) is an anti-fibrotic drug with significant anti-inflammatory property used for treatment of fibrotic conditions such as idiopathic pulmonary fibrosis (IPF).
H. Al-kuraishy, G. Batiha, Hani Faidah, A. Al-Gareeb, H. Saad, J. Simal-Gándara   +5 more
semanticscholar   +1 more source

Imaging diagnosis-computed tomography of traction bronchiectasis secondary to pulmonary fibrosis in a Patterdale Terrier [PDF]

, 2016
An 8-year-old, Patterdale terrier was referred for evaluation of tachypnoea, exercise intolerance, and weight loss. Computed tomographic images showed pneumomediastinum, diffuse pulmonary ground glass opacity, and marked dilatation of peripheral bronchi,
Fitzgerald, E, Lamb, C R, Priestnall, S L   +2 more
core   +2 more sources

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

Immunological Reviews, 2021
The COVID‐19 pandemic rapidly spread around the world following the first reports in Wuhan City, China in late 2019. The disease, caused by the novel SARS‐CoV‐2 virus, is primarily a respiratory condition that can affect numerous other bodily systems ...
A. John, Chitra Joseph, G. Jenkins, Amanda L. Tatler   +3 more
semanticscholar   +1 more source

Physical activity and activity space in patients with pulmonary fibrosis not prescribed supplemental oxygen

BMC Pulmonary Medicine, 2017
Background Patients with pulmonary fibrosis (PF) have impaired quality of life, and research suggests that dyspnea and physical activity are primary drivers. As PF progresses, some patients notice the disease “shrinks their worlds”. The objective of this
Elisabeth Dowling Root, Bridget Graney, Susan Baird, Tara Churney, Kailtin Fier, Majorie Korn, Mark McCormic, David Sprunger, Tomas Vierzba, Frederick S. Wamboldt, Jeffery J. Swigris   +10 more
doaj   +1 more source

A Case Report of Systemic Sclerosis Complicated by Biventricular Heart Failure, Pulmonary Hypertension and Review of Literature [PDF]

, 2017
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder whose aetiology is not fully understood. Skin fibrosis and visceral organs involvement are the hallmarks, and the heart could be disproportionately or subtly involved ...
Akinboro AO, Akinlade M, Akintunde AA, Audu MB   +3 more
core   +1 more source