Results 41 to 50 of about 2,650,471 (308)

Pulmonary complications of HIV infection [PDF]

Respirology, 2007
The lung is a frequent site of opportunistic infection in patients with HIV infection, and noninfectious pulmonary disorders associated with HIV infection and antiretroviral treatments are increasingly common. The severity of immunocompromise, with CD4+ lymphocyte count the most reliable surrogate, is the primary determinant of the risk of developing ...
openaire   +3 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Alveolar cell composition in interstitial lung disease and the development of a pulmonary progressive fibrosing phenotype: a retrospective cohort study

Respiratory Research
Background Immunological bronchoalveolar lavage (iBAL) is a frequently employed diagnostic tool in interstitial lung disease (ILD). The association between iBAL cellular composition and disease progression remains elusive.
Iris A. Simons, Bart G. Boerrigter, Maud C.M. Hovestadt, Kirsten A. Mooij-Kalverda, Shiqi Zhang, Leonoor S. Boers, Anke H. Maitland– van der Zee, Esther J. Nossent, Jan Willem Duitman   +8 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Malnutrition and infection: complex mechanisms and global impacts. [PDF]

, 2007
The authors discuss current concepts and controversies surrounding the complex influences of malnutrition on infection and immunity, and point to practical consequences of countermeasures in acute ...
Schaible Ulrich E, Stefan H E Kaufmann, Schaible, U., Kaufmann, Stefan HE, Kaufmann, S., Schaible, Ulrich E, Kaufmann, Stefan H. E., Schaible, Ulrich E., Kaufmann Stefan H. E, Ulrich E Schaible   +9 more
core   +1 more source

Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution

Nature Communications
Idiopathic pulmonary fibrosis is the most common and aggressive form of interstitial lung disease. Despite extensive research on the pathomechanisms of fibrogenesis, little is known about the mechanisms of fibrosis resolution.
Mahsa Zabihi, Ali Khadim, Arun Lingampally, Ana Ivonne Vazquez-Armendariz, Stefan Hadzic, Georgios-Dimitrios Panagiotidis, Daniel Kalina, Jan Halweg, Tara Procida-Kowalski, Marek Bartkuhn, Xuran Chu, Janine Koepke, Christos Samakovlis, Mario Boehm, Norbert Weissmann, Andreas Günther, Werner Seeger, Peter Braubach, Susanne Herold, Malgorzata Wygrecka, Saverio Bellusci, Elie El Agha   +21 more
doaj   +1 more source

Saccharomyces cerevisiae oesophagitis in a patient with oesophageal carcinoma

Journal of Infection in Developing Countries, 2011
Saccharomyces species are emerging opportunistic fungal pathogens that can cause bloodstream infections in humans. These infections have often been associated with the ingestion of probiotics.
Dimas Alexandre Kliemann, Vicente Sperb Antonello, Luis Carlos Severo, Alessandro Comarú Pasqualotto   +3 more
doaj   +1 more source

Crosstalks between inflammasome and autophagy in cancer

Journal of Hematology & Oncology, 2020
Both inflammasomes and autophagy have important roles in the intracellular homeostasis, inflammation, and pathology; the dysregulation of these processes is often associated with the pathogenesis of numerous cancers.
Chaeuk Chung, Wonhyoung Seo, Prashanta Silwal, Eun-Kyeong Jo   +3 more
doaj   +1 more source

Evaluation of computed tomography images under deep learning in the diagnosis of severe pulmonary infection

Frontiers in Computational Neuroscience, 2023
This work aimed to explore the diagnostic value of a deep convolutional neural network (CNN) combined with computed tomography (CT) images in patients with severe pneumonia complicated with pulmonary infection.
Mao Ming, Na Lu, Wei Qian
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source