Background In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context.
Hirofumi Kamata +13 more
doaj +1 more source
AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid. [PDF]
BACKGROUND: Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV).
Ed Zijlstra +14 more
core +2 more sources
Background Native T1 may be a sensitive, contrast-free, non-invasive cardiovascular magnetic resonance (CMR) marker of myocardial tissue changes in patients with pulmonary artery hypertension.
Laura C. Saunders +11 more
doaj +1 more source
Micronutrient malnutrition and wasting in adults with pulmonary tuberculosis with and without HIV co-infection in Malawi. [PDF]
BACKGROUND: Wasting and micronutrient malnutrition have not been well characterized in adults with pulmonary tuberculosis. We hypothesized that micronutrient malnutrition is associated with wasting and higher plasma human immunodeficiency virus (HIV ...
Johnny J Kumwenda +20 more
core +2 more sources
Prevalence and management of chronic breathlessness in COPD in a tertiary care center
Background Breathlessness is the prominent symptom of chronic obstructive pulmonary disease (COPD). Despite optimal therapeutic management including pharmacological and non-pharmacological interventions, many COPD patients exhibit significant ...
H. Carette +14 more
doaj +1 more source
The role of normal gut microbiota in asthma or ovalbumin (OVA)-induced asthma tolerance (OT) remains unclear. Here, we established mouse models of asthma and OT followed by 2 weeks of antibiotic treatment, to clear the gut microbiota.
Na Li +8 more
doaj +1 more source
Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study [PDF]
Background: Despite advances in HIV treatment, bacterial pneumonia continues to cause considerable morbidity and mortality in patients with HIV infection. Studies of biomarker associations with bacterial pneumonia risk in treated HIV-infected patients do
Brian Angus +30 more
core +1 more source
A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Francis, S. E. +63 more
core +1 more source
Influenza A virus infection predisposes hosts to secondary infection with different Streptococcus pneumoniae serotypes with similar outcome but serotype-specific manifestation. [PDF]
Influenza A virus (IAV) and Streptococcus pneumoniae (S. pn.) are major causes of respiratory tract infections, particularly during co-infection. The synergism between these two pathogens is characterized by a complex network of dysregulated immune ...
Kershaw, Olivia +15 more
core +1 more source
Vagal α7nAChR signaling regulates α7nAChR+Sca1+ cells during lung injury repair
Background The distal airways of the lung and bone marrow are innervated by the vagus nerve. Vagal α7nAChR signaling plays a key role in regulating lung infection and inflammation; however, whether this pathway regulates α7nAChR+Sca1+ cells during lung ...
Xiaoyan Chen +3 more
doaj +1 more source

