Results 21 to 30 of about 37,784 (244)
Frontiers in Bioengineering and Biotechnology, 2021 Tissue engineering using decellularized whole lungs as matrix scaffolds began as a promise for creating autologous transplantable lungs for patients with end-stage lung disease and can also be used to study strategies for lung regeneration ...
Ifeolu Akinnola +13 more
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Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension. [PDF]
PLoS ONE, 2010 Coagulation factor VIII (FVIII) deficiency leads to haemophilia A. Conversely, elevated plasma levels are a strong predictor of recurrent venous thromboemboli and pulmonary hypertension phenotypes in which in situ thromboses are implicated.
Claire L Shovlin +9 more
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Respiratory Research, 2022 Background Despite causing increased morbidity and mortality, pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) patients (COPD-PH) lacks treatment, due to incomplete understanding of its pathogenesis.
Khushboo Goel +11 more
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Materials Today Bio, 2023 This study aimed to investigate the impact of fibroblasts (MRC-5) on the extracellular matrix (ECM) microenvironment of endothelial cells (ECs) during the vascularization of skin-derived ECM hydrogel in vitro.
Meng Zhang +5 more
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Paraquat-Induced Membrane Dysfunction in Pulmonary Microvascular Endothelial Cells [PDF]
Pharmacology and Toxicology, 2000 Membrane dysfunction monitored by lactate dehydrogenase release from cultured pulmonary microvascular endothelial cells of pigs, which were exposed to paraquat at different concentrations (0.1-2 mM), was examined. Paraquat caused a time-dependent increase in lactate dehydrogenase release. Lactate dehydrogenase releases after 72 hr, 32, 58, and 84% by 0.
M, Tsukamoto +3 more
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Mechanical signaling in a pulmonary microvascular endothelial cell monolayer
Biochemical and Biophysical Research Communications, 2019 The mechanical microenvironment of an endothelial cell includes a stable protein scaffold on the basal side, flowing blood on the apical side and contractile cells on the lateral sides. Interaction with the protein scaffold and flowing blood modulates the ability of endothelial cells to migrate, align and maintain barrier function.
Gnyata Patel +6 more
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MiR26-5p inhibits pathological pulmonary microvascular angiogenesis via down-regulating WNT5A [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Pathological micro angiogenesis is a key pathogenic factor in pulmonary diseases such as pulmonary hypertension and hepatopulmonary syndrome.
Jie Chen, Feng Gao, Dan Li, Jinquan Wang
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Pseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells. [PDF]
PLoS ONE, 2013 Pseudomonas aeruginosa uses a type III secretion system to introduce the adenylyl and guanylyl cyclase exotoxin Y (ExoY) into the cytoplasm of endothelial cells.
Ron Balczon +8 more
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Mediators of Inflammation, 2016 Angiotensin II (AngII) caused pulmonary microvascular endothelial barrier injury, which induced acute aortic dissection (AAD) combined with acute lung injury (ALI). However, the exact mechanism is unclear. We investigated the role of dephosphorylation of
Zhiyong Wu +6 more
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SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis
Microbiology Spectrum, 2021 SARS-CoV-2 infection can cause compromised respiratory function and thrombotic events. SARS-CoV-2 binds to and mediates downregulation of angiotensin converting enzyme 2 (ACE2) on cells that it infects.
Soumya Panigrahi +8 more
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