Results 11 to 20 of about 73,571 (236)

Alveolar lipids in pulmonary disease. A review

open access: yesLipids in Health and Disease, 2020
Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is composed by multiple cell types with specialized functions and coordinately acting to meet specific physiologic requirements. The alveoli are the niche of the most
Christina W. Agudelo   +2 more
doaj   +1 more source

Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD).

open access: yesPLoS ONE, 2020
Smoke exposure is known to decrease total pulmonary surfactant and alter its composition, but the role of surfactant in chronic obstructive pulmonary disease (COPD) remains unknown. We aimed to analyze the compositional changes in the surfactant lipidome
Christina W Agudelo   +8 more
doaj   +1 more source

The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels [PDF]

open access: yes, 2013
Aim: Topical administration of siRNA nanocarriers is a promising approach in the treatment of pulmonary disorders. Pulmonary surfactant, covering the entire alveolar surface of mammalian lungs, will be one of the first interfaces that siRNA nanocarriers ...
Braeckmans, Kevin   +4 more
core   +1 more source

The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants [PDF]

open access: yes, 2018
Inhaled nanoparticles traveling through the airways are able to reach the respiratory zone of the lungs. In such event, the incoming particles first enter in contact with the liquid lining the alveolar epithelium, the pulmonary surfactant.
Berret, J. -F., Mousseau, F.
core   +3 more sources

New therapy by surfactant to avoid neuro/psychiatric problems caused by cerebral hypoxia

open access: yesEuropean Psychiatry, 2021
Introduction Covid-19 causes neuro/psychiatric problems by cerebral hypoxia. Objectives My therapy could allow us to cross Covid-19 infection by minimizing both immediate and chronic lung damage and would avoid many deaths and neuro/psychiatric ...
L. Bracco
doaj   +1 more source

Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System [PDF]

open access: yes, 2010
Oxidative stresses from irritants such as hydrogen peroxide and ozone (O_3) can cause dysfunction of the pulmonary surfactant (PS) layer in the human lung, resulting in chronic diseases of the respiratory tract.
Beauchamp, J. L.   +9 more
core   +2 more sources

Restoration of surfactant activity by polymyxin B in lipopolysaccharide-potentiated injury of immature rabbit lungs

open access: yesScientific Reports, 2021
During postnatal adaptation pulmonary surfactant may be inactivated by lipopolysaccharide (LPS). We evaluated the effect of surfactant therapy in combination with antibiotic polymyxin B (PxB) in double-hit model of neonatal lung injury.
Andrea Calkovska   +2 more
doaj   +1 more source

Acute Pathophysiological Effects of Intratracheal Instillation of Budesonide and Exogenous Surfactant in a Neonatal Surfactant-depleted Piglet Model

open access: yesPediatrics and Neonatology, 2010
Chronic lung disease continues to be a major complication in premature infants with severe respiratory distress syndrome (RDS). This is despite having advanced ventilatory care, prenatal corticosteroids, and postnatal surfactant therapies.
Chia-Feng Yang   +5 more
doaj   +1 more source

Pulmonary Surfactants for Acute and Chronic Lung Diseases (Part I)

open access: yesОбщая реаниматология, 2014
Part 1 of the review gives information on the composition and properties of a pulmonary surfactant and quantitative and qual itative impairments in the pulmonary surfactant system in different neonatal and adult abnormalities and describes the ...
O. A. Rozenberg
doaj   +1 more source

Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats [PDF]

open access: yes, 2016
The increasing use of silver nanoparticles (AgNPs) in consumer products is concerning. We examined the potential toxic effects when inhaled in Brown-Norway (BN) rats with a pre-inflammatory state compared to Sprague-Dawley (SD) rats.We determined the ...
Buckley, A   +17 more
core   +1 more source

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