Results 11 to 20 of about 1,404,214 (346)

Pulmonary surfactant inhibition of nanoparticle uptake by alveolar epithelial cells [PDF]

Scientific Reports, 2020
Pulmonary surfactant forms a sub-micrometer thick fluid layer that covers the surface of alveolar lumen and inhaled nanoparticles therefore come in to contact with surfactant prior to any interaction with epithelial cells.
M. Radiom, M. Sarkis, O. Brookes, E. Oikonomou, A. Baeza-Squiban, J. Berret   +5 more
semanticscholar   +1 more source

Reduced levels of pulmonary surfactant in COVID-19 ARDS

Scientific Reports, 2022
To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC ...
P. Schousboe, A. Ronit, H. Nielsen, T. Benfield, L. Wiese, Nikolaos Scoutaris, H. Verder, R. Berg, Povl Verder, R. Plovsing   +9 more
semanticscholar   +1 more source

Effect of Nebulized Bovine Surfactant for Experimental Otitis Media with Effusion [PDF]

Clinical and Experimental Otorhinolaryngology, 2010
ObjectivesIn this study, we evaluated the efficacy of nebulized bovine pulmonary surfactant on experimentally induced otitis media with effusion (OME) in guinea pigs.MethodsTwenty guinea pigs were divided into three groups.
Chul Ho Jang, Yong Bum Cho, Seung Eun Oh, Jeong Uk Choi, Haekyun Park, Cheol Hee Choi   +5 more
doaj   +1 more source

Genetic disorders of the surfactant system: focus on adult disease

European Respiratory Review, 2021
Genes involved in the production of pulmonary surfactant are crucial for the development and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a spectrum of severe monogenic pulmonary diseases in patients of all ages. The
Coline H.M. van Moorsel, Joanne J. van der Vis, Jan C. Grutters   +2 more
doaj   +1 more source

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

Science, 2020
Pitching cGAMP as a vaccine strategy One strategy to address the variable effectiveness of many influenza vaccines is to induce antiviral resident memory T cells, which can mediate cross-protection against multiple substrains (heterosubtypic immunity ...
Ji Wang, Peiyu Li, Yang Yu, Yuhong Fu, Hongye Jiang, Min Lu, Zhiping Sun, Shibo Jiang, Lu Lu, Mei X. Wu   +9 more
semanticscholar   +1 more source

Generation of an induced pluripotent stem cell line from a patient with surfactant metabolism dysfunction carrying ABCA3 mutations

Stem Cell Research, 2021
Surfactant dysfunction is a genetically heterogeneous pulmonary disease that causes dyspnea. ATP binding cassette protein transporter subunit A3 (ABCA3) is the main pathogenic gene of pulmonary surfactant dysfunction.
Xiaojuan Yin, Danhua Zhao, Zhichen Tian, Jia Chen, Jinghan Chi, Yan Ke, Liu He, Xuan Zhang, Yanmei He, Zhichun Feng   +9 more
doaj   +1 more source

Lipid–Protein and Protein–Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis

International Journal of Molecular Sciences, 2020
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air–liquid interface.
O. Cañadas, Bárbara Olmeda, Alejandro Alonso, J. Pérez-Gil   +3 more
semanticscholar   +1 more source

Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result. [PDF]

, 2015
In contrast to the probabilistic way of thinking about pleiotropy as the random expression of a single gene that generates two or more distinct phenotypic traits, it is actually a deterministic consequence of the evolution of complex physiology from the ...
Torday, John S
core   +9 more sources

Alveolar lipids in pulmonary disease. A review

Lipids in Health and Disease, 2020
Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is composed by multiple cell types with specialized functions and coordinately acting to meet specific physiologic requirements. The alveoli are the niche of the most
Christina W. Agudelo, Ghassan Samaha, Itsaso Garcia-Arcos   +2 more
doaj   +1 more source

The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants [PDF]

, 2018
Inhaled nanoparticles traveling through the airways are able to reach the respiratory zone of the lungs. In such event, the incoming particles first enter in contact with the liquid lining the alveolar epithelium, the pulmonary surfactant.
Berret, J. -F., Mousseau, F.
core   +3 more sources