The Role of Pulmonary Surfactants in the Treatment of Acute Respiratory Distress Syndrome in COVID-19 [PDF]
Frontiers in Pharmacology, 2021 Lung alveolar type-II (AT-II) cells produce pulmonary surfactant (PS), consisting of proteins and lipids. The lipids in PS are primarily responsible for reducing the air-fluid surface tension inside the alveoli of the lungs and to prevent atelectasis ...
Shengguang Wang +5 more
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Pulmonary surfactants and the respiratory-renal connection in steroid-sensitive nephrotic syndrome of childhood [PDF]
iScience, 2022 Summary: Steroid-sensitive nephrotic syndrome (SSNS) in childhood is usually due to minimal change disease (MCD). Unlike many glomerular conditions, SSNS/MCD is commonly precipitated by respiratory infections. Of interest, pulmonary inflammation releases
Gabriel Cara-Fuentes +9 more
doaj +2 more sources
Pulmonary Surfactants: a New Therapeutic Target in Asthma. [PDF]
Curr Allergy Asthma Rep, 2020 Lung tissues are highly susceptible to airway inflammation as they are inevitably exposed to inhaled pathogens and allergens. In the lungs, clearance of infectious agents and regulation of inflammatory responses are important for the first-line defense ...
Choi Y, Jang J, Park HS.
europepmc +2 more sources
The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants. [PDF]
Soft Matter, 2018 Inhaled nanoparticles traveling through the airways are able to reach the respiratory zone of the lungs. In such an event, the incoming particles first come into contact with the liquid lining the alveolar epithelium, the pulmonary surfactant.
F. Mousseau, J. Berret
semanticscholar +5 more sources
A Comparison of the Effect of Beractant (Beracsurf) and Proctant Alpha (Curosurf) in Neonatal Respiratory Distress: A Randomized Controlled Trial [PDF]
Iranian Journal of Medical SciencesBackground: Surfactant treatment has revolutionized the management of respiratory distress syndrome (RDS) in preterm infants. The present study compared the effectiveness and adverse effects of two natural surfactants, Beracsurf and Curosurf, in ...
Khadijeh Sadat Najib +3 more
doaj +2 more sources
Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes
Pharmaceutics, 2019 New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are being developed every year, making it vital to find a non-invasive route such as nasal or pulmonary for their administration.
Maliheh Ghadiri +2 more
doaj +2 more sources
Safety and efficacy of pulmonary surfactant therapy for acute respiratory distress syndrome in children: a systematic review and meta-analysis [PDF]
BMC Pulmonary MedicineObjective Pulmonary surfactants (PSs) are generally known to be effective in treating newborns with acute respiratory distress syndrome (ARDS). However, their effectiveness in children remains controversial.
Xuesong Ren +5 more
doaj +2 more sources
Exogenous surfactant for lung contusion causing ARDS: A systematic review of clinical and experimental reports [PDF]
The Clinical Respiratory JournalThis systematic review aimed to summarize the available data on the treatment of pulmonary contusions with exogenous surfactants, determine whether this treatment benefits patients with severe pulmonary contusions, and evaluate the optimal type of ...
Tomáš Merkl +7 more
doaj +2 more sources
Synthetic lung surfactants containing SP-B and SP-C peptides plus novel phospholipase-resistant lipids or glycerophospholipids [PDF]
PeerJ, 2016 Background This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP ...
Robert H. Notter +5 more
doaj +2 more sources
Interfacial mechanisms for stability of surfactant-laden films. [PDF]
PLoS ONE, 2017 Thin liquid films are central to everyday life. They are ubiquitous in modern technology (pharmaceuticals, coatings), consumer products (foams, emulsions) and also serve vital biological functions (tear film of the eye, pulmonary surfactants in the lung).
M Saad Bhamla +4 more
doaj +1 more source