Results 31 to 40 of about 13,172 (206)

Synthesis, Structure–Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers

Pharmaceutics, 2018
Permeability enhancers are receiving increased attention arising from their ability to increase transepithelial permeability and thus, bioavailability of orally or pulmonary administered biopharmaceutics.
Simone Lucarini, Laura Fagioli, Robert Cavanagh, Wanling Liang, Diego Romano Perinelli, Mario Campana, Snjezana Stolnik, Jenny K. W. Lam, Luca Casettari, Andrea Duranti   +9 more
doaj   +1 more source

Pulmonary Surfactants for Acute and Chronic Lung Diseases (Part I)

Общая реаниматология, 2014
Part 1 of the review gives information on the composition and properties of a pulmonary surfactant and quantitative and qual itative impairments in the pulmonary surfactant system in different neonatal and adult abnormalities and describes the ...
O. A. Rozenberg
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In vitro characterization and in vivo comparison of the pulmonary outcomes of Poractant alfa and Calsurf in ventilated preterm rabbits.

PLoS ONE, 2020
Poractant alfa and Calsurf are two natural surfactants widely used in China for the treatment of neonatal respiratory distress syndrome, which are extracted from porcine and calf lungs, respectively.
Xiaojing Guo, Siwei Luo, Davide Amidani, Claudio Rivetti, Giuseppe Pieraccini, Barbara Pioselli, Silvia Catinella, Xabi Murgia, Fabrizio Salomone, Yaling Xu, Ying Dong, Bo Sun   +11 more
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Procedural success and safety of a standardized less invasive surfactant administration protocol using fentanyl premedication and video laryngoscopy in preterm infants <32 weeks’ gestation

Frontiers in Pediatrics
BackgroundLess Invasive Surfactant Administration (LISA) has been established for treating respiratory distress syndrome (RDS) in preterm infants, but the impact of pharmacological analgesia or video laryngoscopy on procedural success and safety remains ...
Mircea-Horia Popa-Todirenchi, Benedikt Bubl, Fabian Keller, Marta Busso, Sophie Jaisli, Lisa Marie Bünte, Marc-Alexander Oestreich, Marc-Alexander Oestreich, André Kidszun   +8 more
doaj   +1 more source

Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients. [PDF]

PLoS ONE, 2013
Pulmonary surfactants are essential components of lung homeostasis. In chronic obstructive pulmonary disease (COPD), surfactant expression decreases in lungs whereas, there is a paradoxical increase in protein expression in plasma.
Soo Jung Um, Stephen Lam, Harvey Coxson, Shu Fan Paul Man, Don D Sin   +4 more
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YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1

iScience, 2021
Summary: Ventilation is dependent upon pulmonary alveoli lined by two major epithelial cell types, alveolar type-1 (AT1) and 2 (AT2) cells. AT1 cells mediate gas exchange while AT2 cells synthesize and secrete pulmonary surfactants and serve as ...
Jason J. Gokey, John Snowball, Anusha Sridharan, Parvathi Sudha, Joseph A. Kitzmiller, Yan Xu, Jeffrey A. Whitsett   +6 more
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COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Mediators of Inflammation, 2021
Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and
Mohamed M. Aboudounya, Richard J. Heads
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Unraveling the enigma: The emerging significance of pulmonary surfactant proteins in predicting, diagnosing, and managing COVID‐19

Immunity, Inflammation and Disease
Background Severe cases of COVID‐19 often lead to the development of acute respiratory syndrome, a critical condition believed to be caused by the harmful effects of SARS‐CoV‐2 on type II alveolar cells.
Mohammad Navid Bastani, Shahram Jalilian
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A case of autoimmune pulmonary alveolar proteinosis with severe respiratory failure treated with segmental lung lavage and oral statin therapy

Respiratory Medicine Case Reports, 2022
Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease characterized by the accumulation of alveolar surfactants due to dysfunction of granulocyte-macrophage colony-stimulating factor-dependent cholesterol clearance.
Tomotsugu Takano, Keisuke Takeda, Satoshi Nakamura, Genta Akiyama, Nobuhisa Ando, Masashi Komori   +5 more
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Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion

BMC Pulmonary Medicine, 2019
Background Bronchoalveolar lavage is a useful bronchoscopy technique. However, studies in “normal” children populations are few. Furthermore, the anti-inflammatory effects of exogenous pulmonary surfactants on the bronchoalveolar cellular components are ...
Lyné van Rensburg, Johann M. van Zyl, Johan Smith, Pierre Goussard   +3 more
doaj   +1 more source