Results 41 to 50 of about 1,349,045 (346)

YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1

iScience, 2021
Summary: Ventilation is dependent upon pulmonary alveoli lined by two major epithelial cell types, alveolar type-1 (AT1) and 2 (AT2) cells. AT1 cells mediate gas exchange while AT2 cells synthesize and secrete pulmonary surfactants and serve as ...
Jason J. Gokey, John Snowball, Anusha Sridharan, Parvathi Sudha, Joseph A. Kitzmiller, Yan Xu, Jeffrey A. Whitsett   +6 more
doaj   +1 more source

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules [PDF]

, 2016
The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability ...
Dave, Vivek S, Gupta, Deepak, Gupta, Sheeba Varghese, Nguyen, Phong, Yu, Monica   +4 more
core   +2 more sources

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Mediators of Inflammation, 2021
Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and
Mohamed M. Aboudounya, Richard J. Heads
doaj   +1 more source

Unraveling the enigma: The emerging significance of pulmonary surfactant proteins in predicting, diagnosing, and managing COVID‐19

Immunity, Inflammation and Disease
Background Severe cases of COVID‐19 often lead to the development of acute respiratory syndrome, a critical condition believed to be caused by the harmful effects of SARS‐CoV‐2 on type II alveolar cells.
Mohammad Navid Bastani, Shahram Jalilian
doaj   +1 more source

A case of autoimmune pulmonary alveolar proteinosis with severe respiratory failure treated with segmental lung lavage and oral statin therapy

Respiratory Medicine Case Reports, 2022
Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease characterized by the accumulation of alveolar surfactants due to dysfunction of granulocyte-macrophage colony-stimulating factor-dependent cholesterol clearance.
Tomotsugu Takano, Keisuke Takeda, Satoshi Nakamura, Genta Akiyama, Nobuhisa Ando, Masashi Komori   +5 more
doaj   +1 more source

Effective critical micellar concentration of a zwitterionic detergent: A fluorimetric study on n-dodecyl phosphocholine [PDF]

, 2010
We have investigated the effect of ionic strength on the aggregation behavior of n-dodecyl phosphocholine. On the basis of the classical Corrin-Harkins relation, the critical micellar concentration of this detergent decreases with a biphasic trend on ...
PALLADINO, PASQUALE, RAGONE, RAFFAELE, ROSSI, FILOMENA   +2 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Lung surfactants and different contributions to thin film stability.

Soft Matter, 2015
The surfactant lining the walls of the alveoli in the lungs increases pulmonary compliance and prevents collapse of the lung at the end of expiration. In premature born infants, surfactant deficiency causes problems, and lung surfactant replacements are ...
Eline Hermans, M. S. Bhamla, P. Kao, G. Fuller, J. Vermant   +4 more
semanticscholar   +1 more source

The Marangoni flow of soluble amphiphiles

, 2013
Surfactant distribution heterogeneities at a fluid/fluid interface trigger the Marangoni effect, i.e. a bulk flow due to a surface tension gradient. The influence of surfactant solubility in the bulk on these flows remains incompletely characterized ...
Cantat, Isabelle, Griffiths, Ian M., Li, Zhenzhen, Roché, Matthieu, Roux, Sébastien Le, Saint-Jalmes, Arnaud, Stone, Howard A.   +6 more
core   +3 more sources

Numerical analysis of the Rayleigh instability in capillary tubes: The influence of surfactant solubility [PDF]

, 2006
A two-dimensional (2D) free surface flow model already used to study the Rayleigh instability of thin films lining the interior of capillary tubes under the presence of insoluble surfactants [D. M. Campana, J. Di Paolo, and F. A.
Campana, Diego Martin, Saita, Fernando Adolfo   +1 more
core   +1 more source