Results 91 to 100 of about 4,197,466 (259)

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension

Respiratory Research, 2019
Background Obesity is associated with cardiovascular complications, including pulmonary hypertension (PH). Reports suggest that peroxisome proliferator-activated receptor-γ (PPARγ) has direct action in preventing vascular remodelling in PH.
Evren Caglayan, Manuela Trappiel, Arnica Behringer, Eva Maria Berghausen, Margarete Odenthal, Ernst Wellnhofer, Kai Kappert   +6 more
doaj   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Right Ventricular Isovolumetric Relaxation Time is Associated with Pulmonary Vascular Load and Functional Limitation in Chronic Obstructive Pulmonary Disease

International Journal of COPD
Fushi Dong,1,2 Yosuke Tanaka,1 Ken Okamura,1 Katsuyuki Higa,1 Shota Kaburaki,1 Yozo Sato,1 Toru Tanaka,1 Ayumi Shimizu,1,3 Susumu Takeuchi,1 Yoshiaki Kubota,4 Namiko Taniuchi,1 Koichiro Kamio,1 Kazuo Kasahara,1 Lina Wu,5 Masahiro Seike,1 Mitsunori Hino,1,
Dong F, Tanaka Y, Okamura K, Higa K, Kaburaki S, Sato Y, Tanaka T, Shimizu A, Takeuchi S, Kubota Y, Taniuchi N, Kamio K, Kasahara K, Wu L, Seike M, Hino M, Kimura H   +16 more
doaj  

Schistosomiasis‐Associated Pulmonary Arterial Hypertension in Brazil: A Call to Action for Enhanced Diagnostic Recognition—2025 Pulmonary Vascular Research Institute Infection in Pulmonary Vascular Disease Consortium Perspectives

Pulmonary Circulation
Schistosomiasis‐associated pulmonary arterial hypertension (Sch‐PAH) is one of the most frequent etiologies of pulmonary arterial hypertension in Brazil and globally.
Camila M. C. Loureiro, Ricardo A. Correa, Roberto José de Carvalho Filho, Brian B. Graham, Ghazwan Butrous, Rudolf K. F. Oliveira   +5 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Exercise and pulsatile pulmonary vascular loading in chronic thromboembolic pulmonary disease

Pulmonary Circulation
Chronic thromboembolic pulmonary disease (CTEPD) is characterized by organized nonresolving thrombi in pulmonary arteries (PA). In CTEPD with pulmonary hypertension (PH), chronic thromboembolic PH (CTEPH), early wave reflection results in abnormalities ...
Sinan Osman, Natasha R. Girdharry, Elizabeth Karvasarski, Robert F. Bentley, Stephen P. Wright, Nadia Sharif, Micheal McInnis, John T. Granton, Marc dePerrot, Susanna Mak   +9 more
doaj   +1 more source

New insights into the pathology of pulmonary hypertension: implication of the miR‐210/ISCU1/2/Fe‐S axis

EMBO Molecular Medicine, 2015
Elevated pulmonary arterial pressure in patients with pulmonary hypertension (PH) is mainly caused by increased pulmonary vascular resistance (PVR), due primarily to sustained pulmonary vasoconstriction and excessive pulmonary vascular remodeling ...
Haiyang Tang, Ramon J Ayon, Jason X‐J Yuan   +2 more
doaj   +1 more source

Impact of Cardiopulmonary Bypass on Pulmonary Hemodynamic Variables

, 2010
Ischemia reperfusion can be the triggering factor of lung injury; subsequently, high pulmonary vascular resistance (PVR) is a crucial risk factor of lung injury after cardiopulmonary bypass (CPB).
Gabriel, Edmo Atique, Salerno, Tomas, Edmo Atique Gabriel, Tomas Salerno   +3 more
core   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source