Results 101 to 110 of about 4,197,466 (259)

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Red Araça (Psidium cattleianum) Extract Prevents Right Ventricular Hypertrophy in Experimental Pulmonary Arterial Hypertension

Biomedicines
Background: Pulmonary artery hypertension (PAH) is characterised by progressive pulmonary vascular remodelling and increased pulmonary vascular resistance, leading to right ventricular (RV) dysfunction and failure. Red araça (Psidium cattleianum) extract
Custódio José Gaspar, Patrick Turck, Alan Bahr, Alexsandra Zimmer, Daniela Drosdowski, Tânia Regina G. Fernandes, Elissa Fernandes, Sílvio Tasca, Vitória Rosa de Oliveira, Felipe Hiran Lino da Silva, Cristina Campos Carraro, Rodrigo Binkowski de Andrade, Eliseu Rodrigues, Carlos Henrique Pagno, Rita de Kássia Souza, Fernanda Visioli, Adriane Belló-Klein, Katya Vianna Rigatto, Alex Sander da Rosa Araujo, Alexandre Luz de Castro   +19 more
doaj   +1 more source

Pulmonary blood pressure, not flow, is associated with net endothelin-1 production in the lungs of patients with congenital heart disease and normal pulmonary vascular resistance.

, 2003
OBJECTIVE: Endothelin-1 concentrations are increased in patients with increased mean pulmonary arterial pressure, pulmonary blood flow, and pulmonary vascular resistance.
Fratz, S;Geiger, R;Kresse, H;Roemer, G;Hennig, M;Sebening, W;Hess, J
core   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Right Ventricular Remodeling in Pulmonary Arterial Hypertension: From Adaptive Compensation to Maladaptive Failure

Cardiovascular Innovations and Applications
Pulmonary arterial hypertension (PAH) comprises a group of progressive pulmonary circulatory diseases characterized by a persistent increase in pulmonary vascular resistance.
Yang Yang, Yichi Zhang, Yuxin Miao, Yang Fang, Haitao Li, Daiji Jiang, Yanghanyue Zhou, Lijun Fu, Hao Zhang, Xike Wang, Yi Yan   +10 more
doaj   +1 more source

Influence of hypoxia on the longitudinal distribution of pulmonary vascular resistance

, 1978
We have examined the influence of hypoxia on the longitudinal distribution of vascular resistance and intravascular pressure in isolated cat lungs using the low-viscosity bolus technique. Hypoxia increased total vascular resistance, decreased total lung
D. J. Grimm, C. A. Dawson, J. H. Linehan
core   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Progressive improvement in pulmonary vascular resistance after percutaneous mitral valvuloplasty.

, 1989
Percutaneous mitral valvuloplasty has been proposed as a nonsurgical technique for treating high-risk patients with mitral stenosis who are deferred from mitral valve replacement.
M J Levine, D J Diver, R G McKay, A D Berman, R M Wyman, J S Weinstein, R D Safian, M J Cunningham, W Grossman   +8 more
core   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source