Results 201 to 210 of about 534,361 (277)

R‐Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS‐STING Pathway Under Inflammatory Microenvironment

Oral Diseases, EarlyView.
ABSTRACT Background R‐Loops are three‐stranded DNA/RNA hybrids implicated in immune responses. Their role in mesenchymal stem cell differentiation, particularly in dental pulp regeneration under inflammation, remains unclear. Methods Rat pulpo‐dentinal complex (PDC) injury models and LPS‐stimulated human dental pulp stem cells (hDPSCs) were used.
Yun Yang, Yiqing Wang, Yating Miao, Zhipu Luo, Lin Niu, Ruirui Liu   +5 more
wiley   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Application of Three Types of Scaffolds in Pulp Regeneration for Permanent Mature Teeth with Periapical Lesions: A Randomized Controlled Trial. [PDF]

Eur Endod J
Alshahhoud A, Rekab MS, Issa N, Manadili A, Alsayed Tolibah Y.   +4 more
europepmc   +1 more source

Periodontal considerations during orthodontic intrusion and extrusion in healthy and reduced periodontium

Periodontology 2000, EarlyView.
Abstract In patients with advanced periodontal disease, pathological tooth migration may occur, which may require subsequent orthodontic treatment for both aesthetic and functional purposes. When planning orthodontic treatment mechanics, intrusive or extrusive forces are frequently indicated.
Gregory S. Antonarakis, Alkisti Zekeridou, Stavros Kiliaridis, Catherine Giannopoulou   +3 more
wiley   +1 more source

Photosensitive Hydrogels Encapsulating DPSCs and AgNPs for Dental Pulp Regeneration. [PDF]

Int Dent J
He Y, Zhang Y, Hu F, Chen M, Wang B, Li Y, Xu H, Dong N, Zhang C, Hu Y, Lin Z, Peng Y, Ye Q, Luo L.   +13 more
europepmc   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Long‐term stability of conventional non‐regenerative periodontal treatment for furcation defects

Periodontology 2000, EarlyView.
Abstract Background Furcation involvement (FI) in multi‐rooted teeth poses significant challenges in periodontal therapy due to complex anatomy and difficulty in achieving effective maintenance. FI is associated with increased periodontal destruction, especially in sites with narrow furcation entrances and deep root concavities.
Guo‐Hao Lin, April Martinez, Vincent Li, Eric Lee, Kang‐Wei Tu, Richard Kao, Hom‐Lay Wang   +6 more
wiley   +1 more source

Advances in Regenerative Dentistry: A Systematic Review of Harnessing Wnt/β-Catenin in Dentin-Pulp Regeneration. [PDF]

Cells
Amir M, Jeevithan L, Barkat M, Fatima SH, Khan M, Israr S, Naseer F, Fayyaz S, Elango J, Wu W, Maté Sánchez de Val JE, Rahman SU.   +11 more
europepmc   +1 more source

Accuracy of surrogate outcomes in predicting true endpoints of surgical periodontal therapy. A narrative review with a 20‐year longitudinal analysis

Periodontology 2000, EarlyView.
Abstract Background Periodontal clinical trials commonly use surrogate end points (e.g., probing pocket depth [PPD], clinical attachment level [CAL], bleeding on probing [BoP], and composite scores such as the Periodontal Risk Score [PRS]) for efficiency, yet tooth loss, treatment burden/cost, and re‐treatment are the definitive patient‐relevant ...
Muhammad H. A. Saleh, Abdusalam E. Alrmali, Fatemeh SamavatiJame, Hamzeh Almanshi, Shahad Alhazmi, Sawsan Abu‐Reyal, Hom‐Lay Wang, Ann Decker   +7 more
wiley   +1 more source