Results 31 to 40 of about 3,654 (184)

Punicalagin Restricts Growth, Promotes Apoptosis, and Reduces Invasion in Human Gastric Cancer Cells

Dose-Response
This research investigated the anticancer properties of punicalagin, a prominent bioactive polyphenol extracted from Punica granatum L, in human gastric cancer cell lines. Normal and gastric cancer cells were exposed to different doses of punicalagin for
Ding-Ping Sun, Yih-Huei Uen, Nai-Wen Kang, Chun-Chao Chang, Yu-Feng Tian, Chia-Lang Fang, Kai-Yuan Lin   +6 more
doaj   +2 more sources

A Systematic Study of the Hepatic–Intestinal First-Pass Effect and Excretion Pathways of Punicalagin Based on UPLC-MS/MS [PDF]

Molecules
Punicalagin, the major polyphenol in pomegranate peel, shows broad bioactivity but suffers from poor oral bioavailability. Whether hepatic or intestinal first-pass processes dominate this limitation remains unresolved. We developed a quantitative UPLC-MS/
Zixin Chen, Zhanying Chang, Pengxia Yao, Xiaoli Gao   +3 more
doaj   +2 more sources

Bioactive potential of punicalagin: A comprehensive review

Applied Food Research
Pomegranates comprise bioactive components including polyphenols, tannins, and anthocyanins, which have demonstrated beneficial health effects. Pomegranates also act as a preventative measure for a variety of ailments, as per the promising results from ...
Irtiqa Shabir, Aamir Hussain Dar, Kshirod Kumar Dash, Sobiya Manzoor, Shivangi Srivastava, Vinay Kumar Pandey, Rafeeya Shams, Iqra Bashir, Shafat Ahmad Khan, Shaikh Ayaz Mukarram, Béla Kovács   +10 more
doaj   +2 more sources

An in vitro antiviral evaluation of punicalagin toward influenza A virus

, 2022
Abstract Background: Influenza complications are mild to serious, and can cause death in some cases. A great deal of attention has been paid in recent years to the development and use of new antiviral compounds for drug resistance in certain strains of the influenza virus and the clinical implications.
Fatemeh Javadi-Farsani, Mohammad-Taghi Moradi, Alijan Tabarraei, Ali Karimi, Mohammad-hadi Razavi Nikoo   +4 more
openaire   +4 more sources

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection [PDF]

Advanced Science
Mycobacterium abscessus (MAB) is an increasingly recognized rapidly growing nontuberculous mycobacterial pathogen whose infection is particularly challenging to treat due to its antibiotic resistance and persistence, necessitating the exploration of ...
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
doaj   +2 more sources

Integrated Phenotypic and Transcriptomic Analyses Unveil the Antibacterial Mechanism of Punicalagin Against Methicillin-Resistant Staphylococcus aureus (MRSA) [PDF]

Foods
The growing emergence of multidrug-resistant bacterial pathogens drives the need for new antibacterial agents. Punicalagin exhibits efficacy against methicillin-resistant Staphylococcus aureus (MRSA), but its specific antibacterial mechanisms remain ...
Yiming Wang, Tianyu Yin, Mengyan Qian, Balarabe B. Ismail, Zhipeng Zou, Xinhui Zhang, Qiao He, Mingming Guo   +7 more
doaj   +2 more sources

Analysis of Punicalin and Punicalagin Interaction with PDIA3 and PDIA1 [PDF]

International Journal of Molecular Sciences
PDIA3 is a pleiotropic protein primarily located in the endoplasmic reticulum where it is involved in protein folding, catalyzing the formation, breakage, and rearrangement of disulfide bonds. PDIA3 is implicated in numerous pathologies such as cancer, inflammation, and neurodegeneration.
Meschiari, Giorgia, Minacori, Marco, Fiorini, Sara, Tedesco, Mariassunta, Eufemi, Margherita, Altieri, Fabio   +5 more
openaire   +4 more sources

Antimicrobial and Immunomodulatory Effects of Punicalagin and Meropenem in a Murine Model of Sublethal Sepsis

Antibiotics
Background: Punicalagin (Pg), a major ellagitannin derived from pomegranates, possesses antimicrobial, antioxidant, and immunomodulatory properties, suggesting its potential as an adjunctive therapy for sepsis.
Liliane dos Santos Rodrigues, Priscila Mendonça Mendes, André Alvares Marques Vale, José Lima Pereira-Filho, Elizabeth Soares Fernandes, Joicy Cortez de Sá Sousa, Márcia Cristina Gonçalves Maciel, Valério Monteiro-Neto   +7 more
doaj   +2 more sources

Punicalagin, a pomegranate polyphenol sensitizes the activity of antibiotics against three MDR pathogens of the Enterobacteriaceae

BMC Complementary Medicine and Therapies
Background Multidrug resistance (MDR) in the family Enterobacteriaceae is a perniciously increasing threat to global health security. The discovery of new antimicrobials having the reversing drug resistance potential may contribute to augment and revive ...
Saba Kiran, Anam Tariq, Shoaib Iqbal, Zubera Naseem, Waqar Siddique, Sobia Jabeen, Rizwan Bashir, Ashfaq Hussain, Moazur Rahman, Fazal-e Habib, Waqar Rauf, Aamir Ali, Yasra Sarwar, Georg Jander, Mazhar Iqbal   +14 more
doaj   +2 more sources

Punicalagin Inhibits African Swine Fever Virus Replication by Targeting Early Viral Stages and Modulating Inflammatory Pathways

Veterinary Sciences
African swine fever (ASF), caused by the African swine fever virus (ASFV), has resulted in significant losses in the global pig industry. Considering the absence of effective vaccines, developing drugs against ASFV may be a crucial strategy for its ...
Renhao Geng, Dan Yin, Yingnan Liu, Hui Lv, Xiaoyu Zhou, Chunhui Bao, Lang Gong, Hongxia Shao, Kun Qian, Hongjun Chen, Aijian Qin   +10 more
doaj   +2 more sources