Results 11 to 20 of about 26,234 (285)

Chemo-Enzymatic Generation of Highly Fluorescent Nucleoside Analogs Using Purine-Nucleoside Phosphorylase [PDF]

Biomolecules
Chemo-enzymatic syntheses of strongly fluorescent nucleoside analogs, potentially applicable in analytical biochemistry and cell biology are reviewed. The syntheses and properties of fluorescent ribofuranosides of several purine, 8-azapurine, and etheno ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski   +1 more
doaj   +4 more sources

Functional and Structural Characterization of Purine Nucleoside Phosphorylase from Kluyveromyces lactis and Its Potential Applications in Reducing Purine Content in Food. [PDF]

PLoS ONE, 2016
Consumption of foods and beverages with high purine content increases the risk of hyperuricemia, which causes gout and can lead to cardiovascular, renal, and other metabolic disorders.
Durga Mahor, Anu Priyanka, Gandham S Prasad, Krishan Gopal Thakur   +3 more
doaj   +2 more sources

Recurrent infections, neurologic signs, low serum uric acid levels, and lymphopenia in childhood: Purine nucleoside phosphorylase deficiency, an emergency for infants. [PDF]

Turk Pediatri Ars, 2020
Purine nucleoside phosphorylase deficiency is one of the severe combined immunodeficiencies, which often clinically manifests with recurrent infections, neurologic symptoms and autoimmune diseases, and leads to thymocyte development and peripheral T cell
Kütükçüler N, Bölük E, Tökmeci N, Karaca NE, Azarsız E, Aksu G, Aykut A.   +6 more
europepmc   +2 more sources

Purine Nucleoside Phosphorylase Deficiency

Atlas of Inherited Metabolic Diseases, 2009
People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
Markus Braun-Falco, Henry J. Mankin, Sharon L. Wenger, Markus Braun-Falco, Stephan DiSean Kendall, Gerard C. Blobe, Christoph K. Weber, Richard Lorenz, Guido Adler, David C. Whitcomb, Dhiraj Yadav, Johannes Bode, Martin Wabitsch, Klaus-Michael Debatin, Pamela Fischer Posovzsky, Akmal Hassan, Mosaad Megahed, Tord M. Lundgren, Markus Pfister, Hans-Peter Zenner, Rossana Berardi, Chiara Pierantoni, Mario Scartozzi, Stefano Cascinu, Geoffrey N. Hendy, Johannes Schwarz, Alexander Storch, John-John B. Schnog, Victor E. A. Gerdes, Susanne A. Schneider, Kailash P. Bhatia, Adriana C. Gittenberger-de Groot, Regina Bökenkamp, Marco C. DeRuiter, Alexander K. C. Leung, Andrew L. Wong, Undine E. Lang, Alexander K. C. Leung, Alexander K. C. Leung, Muammer Seyhan, Silke Hofmann, Leena Bruckner-Tuderman, Silke Hofmann, Leena Bruckner-Tuderman, Silke Hofmann, Leena Bruckner-Tuderman, Peter Kopp, Douglas Forrest, Emine Dibek Misirlioğlu, Nursel Alpan, Mark Oette, Massimo Imazio, Kavitha M. Chinnaiyan, Laxmi S. Mehta, Mushtaq A. Bhat, Javeed I. Bhat, Gerald Stöber, André Reis, Jan Rémi, Soheyl Noachtar, Karin Jurkat-Rott, Frank Lehmann-Horn, Marinella Holzhausen, Nathalie Vergnolle, Martin Schillinger, Hans-Jürgen Gdynia, Albert C. Ludolph, Thomas Namdar, Claus Ferdinand Eisenberger, Wolfram Trudo Knoefel, Pere Ginés, Mónica Guevara, Antonio L. Cuesta-Muñoz, Henk Eijer, Markus Böhm, Thomas A. Luger, Flemming Güttler, Per Guldberg, Richard Koch, Kathryn Moseley, Graeme Eisenhofer, Karel Pacak, James V. Leonard, Jaak Jaeken, Michael A. Becker, Ulrich Stephani, Kendall S. Frazier, Markus Böhm, Thomas A. Luger, Alexander K. C. Leung, Reginald S. Sauve, Verena Matejas, Martin Zenker, Alexander K. C. Leung, Alexander K. C. Leung, William Lane M. Robson, Stefan Beissert, Alexander K. C. Leung, William Lane M. Robson, Tom Y. Woo, Alexander K. C. Leung, Hugo Ten Cate, Richard W. Light, Patricia T. Bozza, Jorge I. Salluh, Michael A. Jantz, Sergio L. Vargas, Rade Tomic, Jesse Roman, Abdullah F. Mobeireek, Mohammad Khalid, Harrys A. Torres, Roy F. Chemaly, Rade Tomic, Jesse Roman, Richard W. Light, Angela Dispenzieri, Sabine Krause, Hanns Lochmüller, Julia Weihrauch, Thomas Krieg, Wolfgang Kühn, Gerd Walz, Georg H. Merker, Ralf Kubitz, Dieter Häussinger, John-John B. Schnog, Victor E. A. Gerdes, Giovanna Musco, Guido Stoll, Klaus V. Toyka, Alexander K. C. Leung, Alexander K. C. Leung, William Lane M. Robson, Markus Böhm, Thomas A. Luger, Elena Pischik, Raili Kauppinen, Jorge Frank, Thomas Schwarz, Manish Thapar, Herbert. L. Bonkovsky, Jeffrey C. Wagner, A. Gordon Smith, Maria Mela, Ulrich Thalheimer, Dimitrios Samonakis, Andrew K. Burroughs, Maria Mela, Ulrich Thalheimer, Dimitrios Samonakis, Andrew K. Burroughs, Yogesh M. Shastri, Jürgen M. Stein, Ronnen H. Segman, Arieh Y. Shalev, Giris Jacob, David Robertson, Alexander K. C. Leung, William Lane M. Robson, Alexander K. C. Leung, Katja Lampinen, Karolina Kublickiene, Risto Kaaja, Radosław Lenarczyk, Oskar Kowalski, Zbigniew Kalarus, Dan Wichterle, Alexander K. C. Leung, Jamie Maguire, Istvan Mody, Katrien Janssens, Filip Vanhoenacker, Wim Van Hul, Hans-Jürgen Gdynia, Albert C. Ludolph, James V. Leonard, Hugo Ten Cate, Karel Geboes, Gert Van Assche, Hugo Ten Cate, Jo H. M. Berden, Toin H. Van Kuppevelt, Angelique L. Rops, Hugo Ten Cate, Hugo Ten Cate, Jorge Frank, Thomas Schwarz, Christina M. Ambros-Rudolph, Valéria Lamounier-Zepter, Christie P. Thomas, Christie P. Thomas, Christie P. Thomas, Christian A. Koch, Lee S. Weinstein, Caroline Silve, Alexander K. C. Leung, Jouni Uitto, Qiujie Jiang, Alexander K. C. Leung   +199 more
openaire   +2 more sources

Purine nucleoside phosphorylase [PDF]

Biomeditsinskaya Khimiya, 2013
Purine nucleoside phosphorylase (PNP) is one of the most important enzymes of the purine metabolism, wich promotes the recycling of purine bases. Nowadays is the actual to search for effective inhibitors of this enzyme which is necessary for creation T-cell immunodeficient status of the organism in the organs and tissues transplantation, and ...
L G, Pogosian, Zh I, Akopian
openaire   +3 more sources

Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase. [PDF]

PLoS ONE, 2014
Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5'-methylthiopurines, byproducts of ...
Teraya M Donaldson, Li-Min Ting, Chenyang Zhan, Wuxian Shi, Renjian Zheng, Steven C Almo, Kami Kim   +6 more
doaj   +2 more sources

Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage [PDF]

Signal Transduction and Targeted Therapy
Influenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown.
Yang Yue, Qingyu Li, Changguo Chen, Juntao Yang, Weian Song, Changdong Zhou, Yuke Cui, Zhenqiao Wei, Qi He, Chenhui Wang, Hongjun Lin, Jiangbo Li, Jian Li, Ji Xi, Xiang Song, Wen Yang, Ze Zhang, Wenjie Shu, Liang Guo, Shengqi Wang   +19 more
doaj   +2 more sources

Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction. [PDF]

Nat Rev Urol, 2022
Birder LA, Jackson EK.
europepmc   +2 more sources

Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts [PDF]

Cancer Reports, 2023
Background Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading‐edge patient‐derived xenografts
Regina Rab, Annette Ehrhardt, Bhagelu R. Achyut, Disha Joshi, Melissa Gilbert‐Ross, Chunzi Huang, Katharine Floyd, Anton V. Borovjagin, William B. Parker, Eric J. Sorscher, Jeong S. Hong   +10 more
doaj   +2 more sources

Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells. [PDF]

J Biol Chem, 2022
Kropotov A, Kulikova V, Solovjeva L, Yakimov A, Nerinovski K, Svetlova M, Sudnitsyna J, Plusnina A, Antipova M, Khodorkovskiy M, Migaud ME, Gambaryan S, Ziegler M, Nikiforov A.   +13 more
europepmc   +2 more sources