Results 31 to 40 of about 24,347 (266)

Nucleotide analogue inhibitors of purine nucleoside phosphorylase.

Journal of Biological Chemistry, 1990
The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major factor contributing to the superior inhibition by this diphosphate over the corresponding mono- and ...
Thomas A. Krenitsky, Joel V. Tuttle, Wayne H. Miller, Allan R. Moorman, G. Faye Orr, Lilia M. Beauchamp   +5 more
openalex   +4 more sources

Engineering a Bifunctional Fusion Purine/Pyrimidine Nucleoside Phosphorylase for the Production of Nucleoside Analogs [PDF]

Biomolecules
Nucleoside phosphorylases (NPs) are pivotal enzymes in the salvage pathway, catalyzing the reversible phosphorolysis of nucleosides to produce nucleobases and α-D-ribose 1-phosphate.
Daniel Hormigo, Jon Del Arco, Javier Acosta, Maximilian J. L. J. Fürst, Jesús Fernández-Lucas   +4 more
doaj   +2 more sources

Purine nucleoside phosphorylase targeted by annexin v to breast cancer vasculature for enzyme prodrug therapy. [PDF]

PLoS ONE, 2013
BACKGROUND AND PURPOSE: The targeting of therapeutics is a promising approach for the development of new cancer treatments that seek to reduce the devastating side effects caused by the systemic administration of current drugs.
John J Krais, Olivier De Crescenzo, Roger G Harrison   +2 more
doaj   +2 more sources

A trimeric structure for mammalian purine nucleoside phosphorylase [PDF]

FEBS Letters, 1973
Yvonne H. Edwards, Paul A. Edwards, D. A. HOPKINSON   +2 more
openalex   +5 more sources

Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients

Annals of Saudi Medicine, 2009
Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive metabolic disorder that results in combined immunodeficiency, neurologic dysfunction and autoimmunity.
Alangari Abdullah, Al-Harbi Abdullah, Al-Ghonaium Abdulaziz, Santisteban Ines, Hershfield Michael   +4 more
doaj   +2 more sources

Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice

Neurobiology of Disease, 2012
Inherited defects in purine nucleoside phosphorylase (PNP) cause severe T cell immunodeficiency and progressive neurological dysfunction, yet little is known about the effects of PNP deficiency on the brain.
Alireza Mansouri, Weixian Min, Christina J. Cole, Sheena A. Josselyn, Jeffrey Theodore Henderson, Matthijs van Eede, R. Mark Henkelman, Cameron Ackerley, Eyal Grunebaum, Chaim M. Roifman   +9 more
doaj   +4 more sources

Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. [PDF]

PLoS ONE, 2011
Pancreatic Adenocarcinoma (PDAC), the fourth highest cause of cancer related deaths in the United States, has the most aggressive presentation resulting in a very short median survival time for the affected patients. Early detection of PDAC is confounded
Shaiju K Vareed, Vadiraja B Bhat, Christopher Thompson, Vihas T Vasu, Damian Fermin, Hyungwon Choi, Chad J Creighton, Sitaram Gayatri, Ling Lan, Nagireddy Putluri, Gagan Singh Thangjam, Punit Kaur, Mohsen Shabahang, Judith G Giri, Alexey I Nesvizhskii, Alexander A A Asea, Anil G Cashikar, Arundhati Rao, James McLoughlin, Arun Sreekumar   +19 more
doaj   +5 more sources

8‐Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1 [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background 8‐Aminoguanosine and 8‐aminoguanine are K+‐sparing natriuretics that increase glucose excretion. Most effects of 8‐aminoguanosine are due to its metabolism to 8‐aminoguanine.
Edwin K. Jackson, Zaichuan Mi, Thomas R. Kleyman, Dongmei Cheng   +3 more
doaj   +2 more sources

Cloning and expression of recombinant purine nucleoside phosphorylase in the methylotrophic yeast Pichia pastoris

Journal of Advanced Biotechnology and Experimental Therapeutics, 2023
Purine Nucleoside Phosphorylase (PNP) is an enzyme involved in biosynthetic pathway of purine nucleosides. Purine nucleoside phosphorylase catalyzes the cleavage of the glycosidic bond of ribo- or deoxyribonucleosides to form the purine base and ...
Jaloliddin Abdurakhmanov, Sobirdjan Sasmakov, Shukhrat Khasanov, Oybek Ashirov, Farkhod Eshboev, Khayotjon Dolimov, Saodat Gaynazarova, Tulkin Sadullaev, Oygul Yarilkaganova, Khusan Nasriddinov, Asadali Baymirzaev, Artyom Makhnyov, Shakhnoz Azimova   +12 more
doaj   +1 more source

Investigating the Vital Role of the Identified Abietic Acid from Helianthus annuus L. Calathide Extract against Hyperuricemia via Human Embryonic Kidney 293T Cell Model

Molecules, 2023
To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai, Xiao Xu, Wannan Li, Xueqi Fu, Weiwei Han, Guodong Li   +5 more
doaj   +1 more source