Some inhibitors of purine nucleoside phosphorylase [PDF]
Biomeditsinskaya Khimiya, 2011 Purine nucleoside phosphorylase (PNP) catalyzes reversible phosphorolysis of purine deoxy- and ribonucleosides with formation (d)Rib-1-P and corresponding bases. PNP plays a leading role in the cell metabolism of nucleosides and nucleotides, as well as in maintaining the immune status of an organism.
J. I. Akopian +4 more
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Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]
, 2020 The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T. +9 more
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Thermodynamic reaction control of nucleoside phosphorolysis [PDF]
, 2020 Nucleoside analogs represent a class of important drugs for cancer and antiviral treatments. Nucleoside phosphorylases (NPases) catalyze the phosphorolysis of nucleosides and are widely employed for the synthesis of pentose‐1‐phosphates and nucleoside ...
Giessmann, Robert T. +4 more
core +1 more source
Purine Nucleoside Phosphorylase Deficiency [PDF]
Arthritis & Rheumatism, 1979 AbstractThe biochemical features of two families with purine nucleoside phosphorylase deficiency are compared. Laboratory studies and an evaluation of kinetic and physical properties of erythrocyte purine nucleoside phosphorylase give evidence that a) the degree of abnormality in uric acid and nucleoside concentrations in plasma and urine reflect the ...
Irving H. Fox +7 more
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PNP inhibitors selectively kill cancer cells lacking SAMHD1
Molecular & Cellular Oncology, 2020 Purine nucleoside phosphorylase inhibitors (PNP-Is) were developed to ablate transformed lymphocytes. However, only some patients with leukemia benefit from PNP-Is. We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase
Tamara Davenne, Jan Rehwinkel
doaj +1 more source
Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms [PDF]
, 2013 <p>Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.</p> <p>Methodology/Principal ...
A Hofer +51 more
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Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis [PDF]
, 2005 Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since ...
Blagova, E V +6 more
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Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]
, 1990 The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna +32 more
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Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu +7 more
doaj +1 more source
An unusual presentation of purine nucleoside phosphorylase deficiency mimicking systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome. [PDF]
Pediatr Rheumatol Online J, 2019 Arduini A +9 more
europepmc +3 more sources