Results 81 to 90 of about 14,227 (210)

Circulating Human Neonatal Naïve B cells are Deficient in CD73 Impairing Purine Salvage

Frontiers in Immunology, 2016
Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate (ATP), are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood may influence their function
Matthew Aaron Pettengill, Ofer eLevy, Ofer eLevy   +2 more
doaj   +1 more source

Myocardial release of hypoxanthine and lactate during percutaneous transluminal coronary angioplasty [PDF]

, 1989
The response of myocardial lactate and hypoxanthine metabolism during percutaneous transluminal coronary angioplasty was studied in a series of 15 patients undergoing this procedure.
Brand, M.J.B.M. (Marcel) van den, Feyter, P.J. (Pim) de, Harmsen, E., Hugenholtz, P.G. (Paul), Jong, J.W. (Jan Willem) de, Piscione, F., Serruys, P.W.J.C. (Patrick), Suryapranata, H. (Harry)   +7 more
core   +1 more source

Role of Toll‐Like Receptors in Myeloid Neoplasms: Focuses on the Molecular Mechanisms and Clinical Impact on Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myeloid Leukemia

APMIS, Volume 133, Issue 9, September 2025.
ABSTRACT Toll‐like receptors (TLRs) are essential components of the innate immune system, functioning as pattern recognition receptors (PRRs) to detect pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs). In hematological malignancies, particularly myelodysplastic syndromes (MDS), acute myeloid leukemia (AML),
Clarissa Brenda Alves Cavalcante, Alessandro Cavalcante Chaves, Vanessa Silva de Oliveira, Maria Amanda Silva de Araújo, Thayres Marinho Cunha e Silva, João Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro‐Junior   +8 more
wiley   +1 more source

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties.

PLoS ONE, 2018
Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development of new tools that predict molecular properties related to pharmacological potential.
Jefferson A Rocha, Nayra C S Rego, Bruna T S Carvalho, Francisco I Silva, Jose A Sousa, Ricardo M Ramos, Ionara N G Passos, Josué de Moraes, Jose R S A Leite, Francisco C A Lima   +9 more
doaj   +1 more source

An improved technique for isolated perfusion of rat livers and an evaluation of perfusates [PDF]

, 1992
We have modified the apparatus for isolated rat liver perfusion (IPRL) in order to be able to perform two perfusions simultaneously. In addition, we studied the quality and stability of livers by comparison of five different perfusates: Blood (Group A ...
Liu, T, Mischinger, HJ, Nakamura, K, Rao, PN, Rubin, R, Starzl, TE, Todo, S, Walsh, TR   +7 more
core   +1 more source

Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism

npj Science of Food
Reducing intestinal absorption by degrading purine nucleosides has been shown to alleviate hyperuricemia (HUA). The probiotic Pediococcus acidilactici GR-5, derived from the traditional food “Jiangshui”, achieved efficient degradation of purine ...
Jing Ji, Zi-Yi An, Aman Khan, Liang Peng, Sourabh Kulshreshtha, El-Sayed Salama, Hui Yun, Pu Liu, Wei-Lin Jin, Xiangkai Li   +9 more
doaj   +1 more source

Analysis of Multiple Isoenzyme Expression Among Twenty-Two Species of Mycoplasma and Acholeplasma [PDF]

, 1981
Crude extracts of triple-cloned, purified cultures of 22 species of Mycoplasma and Acholeplasma were examined for expression of 21 isozyme systems routinely used to type mammalian cells. Nine previously described enzymes (purine nucleoside phosphorylase,
Barile, Michael F., Grabowski, Marion W., O\u27Brien, Stephen J., Simonson, Janice M.   +3 more
core   +1 more source

Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients

Annals of Saudi Medicine, 2009
Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive metabolic disorder that results in combined immunodeficiency, neurologic dysfunction and autoimmunity.
Alangari Abdullah, Al-Harbi Abdullah, Al-Ghonaium Abdulaziz, Santisteban Ines, Hershfield Michael   +4 more
doaj  

Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]

, 2019
Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J., Hafen, Paul S., Miller, Spencer G.   +2 more
core   +1 more source

The antiepileptic potential of nucleosides [PDF]

, 2014
Despite newly developed antiepileptic drugs to suppress epileptic symptoms, approximately one third of patients remain drug refractory. Consequently, there is an urgent need to develop more effective therapeutic approaches to treat epilepsy. A great deal
Dobolyi, Á., Juhász, G., Kovács, Z., Kékesi, K .A.   +3 more
core   +1 more source