Results 81 to 90 of about 20,168 (266)

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, Volume 12, Issue 14, July 25, 2025.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

Tri-Cyclic Nucleobase Analogs and Their Ribosides as Substrates of Purine-Nucleoside Phosphorylases. II Guanine and Isoguanine Derivatives

Molecules, 2019
Etheno-derivatives of guanine, O6-methylguanine, and isoguanine were prepared and purified using standard methods. The title compounds were examined as potential substrates of purine-nucleoside phosphorylases from various sources in the reverse ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Michał Górka, Agnieszka Bzowska, Beata Wielgus-Kutrowska   +4 more
doaj   +1 more source

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

Purine Nucleoside Phosphorylase: Allosteric Regulation of a Dissociating Enzyme

Journal of Biological Chemistry, 1991
Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is a trimeric enzyme that readily dissociates to the monomer. Dilution of enzyme from 20 to 0.02 microgram of protein/ml is accompanied by a greater than 50-fold increase in the specific activity (vtrimer = 0.23 nmol/min/microgram; vmonomer = 12.5 nmol/min/micrograms).
T W, Traut, P A, Ropp, A, Poma
openaire   +5 more sources

Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: Identification of a novel citraconate‐mediated pathway

European Journal of Heart Failure, Volume 27, Issue 7, Page 1342-1352, July 2025.
Aims Although functional recovery of the failing heart with left ventricular assist device (LVAD) unloading can occur, the underpinning mechanism is unclear. We aimed to characterize the effect of myocardial biochemical effect of LVAD support in vivo and in vitro.
David M. Kaye, Xiao Suo Wang, Yen Chin Koay, Mengbo Li, Bailey McIntosh, Yann Huey Ng, Michael Rahman, Yiyang Cao, Francine Z. Marques, Cassandra Malecki, Shane Nanayakkara, Justin Mariani, Bing Wang, Sean Lal, Giovanni Guglielmi, John F. O'Sullivan   +15 more
wiley   +1 more source

Purine nucleoside phosphorylase in chronic lymphocytic leukemia (CLL) [PDF]

Blood, 1978
Purine nucleoside phosphorylase (PNP), the enzyme schematically next to adenosine deaminase in the purine salvage pathway, has been demonstrated cytochemically in peripheral blood lymphocytes of healthy subjects and chronic lymphocytic leukemia (CLL) patients. The enzyme activity is confined to the cytosol.
J. De Cree, M. Borgers, W. De Cock, M. De Brabander, Herman Verhaegen, G. Geuens, Fred Thoné   +6 more
openaire   +4 more sources

Purine nucleoside phosphorylase activity in acute lymphoblastic leukemia [PDF]

Blood, 1980
Purine nucleoside phosphorylase (PNP) activity has been measured in the lymphoblasts of 22 patients with acute lymphoblastic leukemia (ALL) and correlated with routine immunologic cell surface markers. Fourteen of the 22 patients were considered to have non-T, non-B-cell ALL; 8 patients had T-cell disease.
Neil Levin, Gregory H. Reaman, Julie Blatt, David G. Poplack   +3 more
openaire   +4 more sources

Rapid and chemically diverse C transfer from trees to mycorrhizal fruit bodies in the forest

Functional Ecology, Volume 39, Issue 6, Page 1343-1357, June 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Ectomycorrhizal fungi (EMF) are common belowground tree symbionts, supplying trees with water and nutrients. In return, large amounts of C assimilated by trees can be allocated into EMF. However, the chemical forms in which the C is transferred from trees to fungi under
Alon Rapaport, Stav Livne‐Luzon, Hagar Fox, Yaara Oppenheimer‐Shaanan, Tamir Klein   +4 more
wiley   +1 more source

Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant

Annals of Indian Academy of Neurology, 2019
We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay.
Nikit Shah, Lokesh Lingappa, Ramesh Konanki, Sirisha Rani, Ramprasad Vedam, Sakthivel Murugan   +5 more
doaj   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source