Results 101 to 110 of about 209,598 (340)

Probiotics in Alleviating Hyperuricemia: Research Status, Mechanism of Action and Challenges

Shipin gongye ke-ji
Hyperuricemia (HUA) is a chronic metabolic disease, characterized by excessive uric acid in the blood, caused by purine metabolism disorders. Studies show that conventional clinical treatment methods have certain limitations, while probiotics have the ...
Xinru YANG, Jiayue TANG, Xiaoqun ZENG, Zhen WU, Qiwei DU, Maolin TU   +5 more
doaj   +1 more source

Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Discovery of an improved prebiotic method for the synthesis of ribonucleosides provides support to theories that posit a central role for RNA in the origin of life. It has been assumed that ribonucleosides arose through an abiotic process in
Inho Nam, H. Nam, R. Zare
semanticscholar   +1 more source

Establishment of a novel cynomolgus monkey model of hyperuricemia

Animal Models and Experimental Medicine, EarlyView.
We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang, Le Zhang, Can Yang, Guan‐Cong Luo, Rui‐Chang Liu, Yan‐Jun Xu, Sheng Cheng, Wen‐Yu Jiang, Richard Ward, Yang Yang, Cheng Xiang, Shu An, Tian‐Rui Xu   +12 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

Nature Communications, 2017
Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Shaun Stairs, Arif Nikmal, Dejan-Krešimir Bučar, Shao-Liang Zheng, J. Szostak, M. Powner   +5 more
semanticscholar   +1 more source

Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors

International Journal of Molecular Sciences, 2018
The growing evidence of the involvement of purine compounds in signaling, of nucleotide imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light on purine metabolism, indicating that well known biochemical pathways may ...
M. Garcia-Gil, M. Camici, S. Allegrini, R. Pesi, Edoardo Petrotto, M. Tozzi   +5 more
semanticscholar   +1 more source

Phasentrennung von Nukleinsäuren: Mechanismen, Eigenschaften und Anwendungen

Angewandte Chemie, EarlyView.
Jüngste Entdeckungen zeigen, dass einzelsträngige langkettige Nukleinsäuren temperaturinduziert phasentrennen und dabei mikrometergroße Kondensate bilden. Dieser Minireview fasst das aktuelle mechanistische Verständnis dieses Phänomens zusammen, beschreibt Strategien zur gezielten Kontrolle der physikalischen und chemischen Eigenschaften der Kondensate
Weixiang Chen, Johann Fritzen, Andreas Walther   +2 more
wiley   +1 more source

Purine metabolism controls innate lymphoid cell function and protects against intestinal injury

Immunology and Cell Biology, 2018
Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including IBD. However, the
Siobhan Crittenden, A. Cheyne, A. Adams, T. Forster, C. Robb, J. Felton, G. Ho, Dominik Ruckerl, A. Rossi, S. Anderton, P. Ghazal, J. Satsangi, S. Howie, Chengcan Yao   +13 more
semanticscholar   +1 more source

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications

Angewandte Chemie International Edition, EarlyView.
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen, Johann Fritzen, Andreas Walther   +2 more
wiley   +1 more source

Clinical Significance of Gut Microbiota Community Types for Long‐Term Response to Fecal Microbiota Transplantation in Patients With Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Fecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment were associated with long‐term response to FMT.
Panpan Qin, Maja S. Kragsnaes, Dorte K. Holm, Hans Christian Horn, Anna Christine Nilsson, Jens Kjeldsen, Karsten Kristiansen, Torkell Ellingsen   +7 more
wiley   +1 more source