Results 121 to 130 of about 311,690 (329)

Overcoming EGFR‐Mediated Dendritic Cell Dysfunction to Enhance Anti‐tumor Immunity in EGFR‐Mutant NSCLC by Precisely Targeting CD73 With pH‐responsive Nanocarriers

Advanced Science, EarlyView.
EGFR mutations drive ERK/c‐Jun–mediated transcriptional activation of CD73, elevating adenosine levels and fostering an immunosuppressive TME by impairing DC maturation and CD8⁺ T cell priming. The pH‐responsive nanodrug F127ZIF‐8AB680 selectively inhibits CD73, normalizes adenosine metabolism, and re‐establishes effective anti‐tumor immunity ...
Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, Yanguo Liu   +14 more
wiley   +1 more source

Electrochemical ⍺‐C─H Functionalization of Nitramines for Accessing Bifunctional Energetic Heterocycles

Angewandte Chemie, EarlyView.
An electrochemical α‐C─H functionalization of nitramines enables the synthesis of molecules containing bifunctional energetic heterocycles with promising properties. A telescoped, HNO3‐free sequence involving nitration and azolation steps offers a safer, modular, and scalable platform for the synthesis of energetic compounds.
Wan‐Chen Cindy Lee, Luiz F. T. Novaes, Rojan Ali, Thomas Wirth, Song Lin   +4 more
wiley   +2 more sources

Effects of Different Packaging on the Purine Content and Key Enzymes of Refrigerated Yellow Croaker (Larimichthys crocea)

Foods
In this study, we investigated the effects of air packaging, vacuum packaging and modified atmosphere packaging (CO2/N2: 80/20) on the purine metabolism and enzyme activities of refrigerated large yellow croakers.
Tiansheng Xu, Wenxuan Lu, Bohan Chen, Dapeng Li, Jing Xie   +4 more
doaj   +1 more source

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

Nature Communications, 2017
Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Shaun Stairs, Arif Nikmal, Dejan-Krešimir Bučar, Shao-Liang Zheng, J. Szostak, M. Powner   +5 more
semanticscholar   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Sequence-specific recognition of a coding segment of human DACH1 gene via short pyrimidine/purine oligonucleotides

, 2021
Shoaib Khan, Anju Singh, Nishu Nain, Srishty Gulati, Shrikant Kukreti   +4 more
openalex   +2 more sources

Allantoin, a stress-related purine metabolite, can activate jasmonate signaling in a MYC2-regulated and abscisic acid-dependent manner

Journal of Experimental Botany, 2016
Highlight Allantoin, a stress-related purine metabolite, can activate JA responses via ABA in Arabidopsis, suggesting its possible involvement in the homeostasis of these phytohormones and their interplay in stress signaling.
H. Takagi, Y. Ishiga, Shunsuke Watanabe, T. Konishi, M. Egusa, Nobuhiro Akiyoshi, Takakazu Matsuura, I. Mori, T. Hirayama, H. Kaminaka, H. Shimada, A. Sakamoto   +11 more
semanticscholar   +1 more source

Chromatographic studies of nucleic acids. 1. A technique for the identification and estimation of purine and pyrimidine bases, nucleosides and related substances [PDF]

, 1949
Roy Markham, Johan Smith
openalex   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Late‐Stage Conversion of Terminal Alkynes to Nitriles in Nucleoside Scaffolds: A Tool for Diversification

Asian Journal of Organic Chemistry, EarlyView.
We established a metal‐free, late‐stage diversification of terminal alkynes into nitriles using tert‐butyl nitrite (tBuONO). Replacing 2‐picoline N‐oxide with N‐methylmorpholine N‐oxide (NMO) as the oxidant enabled efficient nitrile formation under mild conditions. Abstract The small nucleoside molecule LJ‐4827 exhibited potent kinase inhibition and in
Yun A Yum, Vikas R. Aswar, Vidyasagar Gaikwad, Sushil K. Tripathi, Dnyandev B. Jarhad, Lak Shin Jeong   +5 more
wiley   +1 more source