Results 121 to 130 of about 187,335 (337)

Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy.

Blood, 1997
The immune-mediated graft-versus-leukemia effect is important to prevent relapse after allogeneic progenitor cell transplantation. This process requires engraftment of donor immuno-competent cells.
S. Giralt, E. Estey, M. Albitar, K. Besien, G. Rondon, P. Anderlini, S. O’Brien, I. Khouri, J. Gajewski, R. Mehra, D. Claxton, B. Andersson, M. Beran, D. Przepiorka, C. Koller, S. Kornblau, M. Korbling, M. Keating, H. Kantarjian, R. Champlin   +19 more
semanticscholar   +1 more source

The Safeguarding Microglia: Central Role for P2Y12 Receptors

Frontiers in Pharmacology, 2021
Si-Si Lin, Si-Si Lin, Yong Tang, Yong Tang, Peter Illes, Peter Illes, Peter Illes, Alexei Verkhratsky, Alexei Verkhratsky, Alexei Verkhratsky   +9 more
doaj   +1 more source

Transport proteins of parasitic protists and their role in nutrient salvage

Frontiers in Plant Science, 2014
The loss of key biosynthetic pathways is a common feature of important parasitic protists, making them heavily dependent on scavenging nutrients from their hosts.
Paul eDean, Peter eMajor, Sirintra eNakjang, Robert eHirt, T Martin eEmbley   +4 more
doaj   +1 more source

Probiotics in Alleviating Hyperuricemia: Research Status, Mechanism of Action and Challenges

Shipin gongye ke-ji
Hyperuricemia (HUA) is a chronic metabolic disease, characterized by excessive uric acid in the blood, caused by purine metabolism disorders. Studies show that conventional clinical treatment methods have certain limitations, while probiotics have the ...
Xinru YANG, Jiayue TANG, Xiaoqun ZENG, Zhen WU, Qiwei DU, Maolin TU   +5 more
doaj   +1 more source

BIOSYNTHESIS OF THE PURINES

, 1956
Standish C. Hartman, Bruce Levenberg, John M. Buchanan   +2 more
openalex   +2 more sources

Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages

Applied Sciences
Cyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation.
Simona Todisco, Vittoria Infantino, Anna Caruso, Anna Santarsiero, Paolo Convertini, Hussein El-Kashef, Federica Giuzio, Maria Stefania Sinicropi, Carmela Saturnino   +8 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Metabolic mechanism of dietary factors and effect of dietary types associated with hyperuricemia: a review

Food Science and Human Wellness
Globally, hyperuricemia is a growing health, social, and economic problem which could cause gout, chronic kidney diseases and other diseases. There are increasing evidences that a sensible diet makes sense to reduce the risk of hyperuricemia. This review
Kaina Qiao, Xuewei Zhou, Lili Zhang, Wangang Zhang, Baoguo Sun, Yuyu Zhang   +5 more
doaj   +1 more source

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

The Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan, William A. McLellan, Sentiel A. Rommel, Alexander M. Costidis, Craig A. Harms, J. G. M. Thewissen, Susan J. Rehorek, David S. Rotstein, Mark D. Gay, Alison R. Taylor, Heather N. Koopman, Ying Wang, Stephanie Kamel, D. Ann Pabst   +13 more
wiley   +1 more source

Characterization of Guanine Deaminase from Kluyveromyces marxianus and Its Industrial Application to Reduce Guanine Content in Beer

Foods
Guanine deaminase (GDA) catalyzes the first step in purine catabolism by converting guanine to xanthine. Despite its significant role in the development of low-purine food, studies on GDA remain limited compared to other metabolic deaminases. To identify
Peng Zhou, Junhao Xu, Zixuan Wang, Baoguo Li, Zhijun Zhao   +4 more
doaj   +1 more source