Results 141 to 150 of about 124,162 (316)
The Photophysics of Nucleic Acids: Consequences for the Emergence of Life
ChemSystemsChem, Volume 5, Issue 1, January 2023., 2023 Photochemical reactions in nucleic acids induced by ultraviolet (UV) radiation could have played an important role in the prebiotic selection of the building blocks of life. This Review summarizes the quantum efficiencies of the photorelaxation pathways of nucleic acids and discusses its implications for the emergence of an initial sequence pool on ...
Corinna L. Kufner +2 more
wiley +1 more source
The estimation of purines in nucleic acids: a method applicable to materials with low concentration of nucleic acid [PDF]
, 1954 I. W. McDonald
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Light‐responsive mononucleotide coacervates
Chemistry – A European Journal, Accepted Article.Liquid‐liquid phase separation (LLPS) is central to the formation of biomolecular condensates in modern cells and is also explored as a mechanism for assembling protocells. Phase‐separated droplets provide dynamic micro‐environments that concentrate reactants, enhance reactions, and allow molecular exchange, essential for both cellular regulation and ...
Edison Rafael Jimenez Granda +4 more
wiley +1 more source
ChemSystemsChem, Volume 5, Issue 1, January 2023., 2023 Without catalyst! A non‐enzymatic, spontaneous route to the formation of short, mixed‐sequence RNA strands from 2′,3′‐cyclic ribonucleotides is shown. The reaction occurs by drying at the air–water interfaces. Abstract For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step.
Avinash Vicholous Dass +16 more
wiley +1 more source
Mechanisms of Synthesis of Purine Nucleotides in Heart Muscle Extracts1 [PDF]
, 1957 David A. Goldthwait
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Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy
ChemPlusChem, Accepted Article.The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber +3 more
wiley +1 more source
The Chemical Record, Volume 22, Issue 12, December 2022., 2022 Three generations of neutral and anionic water‐soluble palladium complexes act as versatile catalysts for the modification of unprotected halonucleosides. Abstract Modification of unprotected nucleosides has been attracting continuous interest, since these building blocks themselves and their phosphate‐upgraded corresponding nucleotides have shown a ...
José Luis Serrano
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ChemPhotoChem, EarlyView.The combination of continuous flow technology and visible light photocatalysis has been used to improve the safety and productivity of reactions with diazonium salts as reactive intermediates. This approach has proven to be a reliable method for various organic synthesis routes with diazonium salts under mild and well‐defined conditions.
Christoph Deckers, Thomas H. Rehm
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Environmental Toxicology, Volume 38, Issue 1, Page 90-100, January 2023., 2023 Abstract Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair enzyme methyl guanine methyltransferase (MGMT), which removes methyl groups from purine bases, counteracts
Ai Mai +6 more
wiley +1 more source