Results 141 to 150 of about 311,690 (329)

Phenotypic and Genotypic Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Related to Persistent Endovascular Infection. [PDF]

, 2019
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (PB) represents an important subset of S. aureus infection and correlates with poor clinical outcomes.
Bayer, Arnold S, Li, Liang, Xiong, Yan Q, Yeaman, Michael R   +3 more
core   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Metabolic mechanism of dietary factors and effect of dietary types associated with hyperuricemia: a review

Food Science and Human Wellness
Globally, hyperuricemia is a growing health, social, and economic problem which could cause gout, chronic kidney diseases and other diseases. There are increasing evidences that a sensible diet makes sense to reduce the risk of hyperuricemia. This review
Kaina Qiao, Xuewei Zhou, Lili Zhang, Wangang Zhang, Baoguo Sun, Yuyu Zhang   +5 more
doaj   +1 more source

Synthesis, Antiproliferative Activity, and ADME Profiling of Novel Racemic and Optically Pure Aryl-Substituted Purines and Purine Bioisosteres

Biomolecules
The aim of this study was to synthesize new racemic and optically pure aryl-substituted purine bioisosteres using ultrasound-assisted Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition.
Martina Piškor, Astrid Milić, Sanja Koštrun, Maja Majerić Elenkov, Petra Grbčić, Sandra Kraljević Pavelić, Krešimir Pavelić, Silvana Raić-Malić   +7 more
doaj   +1 more source

Clinical Significance of Gut Microbiota Community Types for Long‐term Response to Fecal Microbiota Transplantation in Patients with Psoriatic Arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Fecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment associated with long‐term response to FMT.
Panpan Qin, Maja S. Kragsnaes, Dorte K. Holm, Hans Christian Horn, Anna Christine Nilsson, Jens Kjeldsen, Karsten Kristiansen, Torkell Ellingsen   +7 more
wiley   +1 more source

Gene Expression Analysis of HPRT-Deficient Cells Maintained with Physiological Levels of Folic Acid

Cells
Lesch–Nyhan disease (LND) is associated with a complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity due to mutations in the HPRT1 gene.
Rosa J. Torres, Gerard Valentines-Casas, Claudia Cano-Estrada, Neus Ontiveros, José M. López   +4 more
doaj   +1 more source

Effects of strand and directional asymmetry on base-base coupling and charge transfer in double-helical DNA [PDF]

, 2002
Mechanistic models of charge transfer (CT) in macromolecules often focus on CT energetics and distance as the chief parameters governing CT rates and efficiencies.
Barton, Jacqueline K., O'Neill, Melanie A.   +1 more
core  

POPULATION DYNAMICS OF PURINE AND PYRIMIDINE ANALOG SENSITIVE AND RESISTANT MAMMALIAN CELLS GROWN IN CULTURE1 2 [PDF]

, 1972
John Morrow
openalex   +1 more source

Classic Hairy Cell Leukemia With MAP2K1 Mutation: Diagnosis and Targeted Therapy

American Journal of Hematology, EarlyView.
Andrea Duminuco, Alessandra Venanzi, Alessia Santi, Alessandro Mancini, Alessandra Romano, Enrico Tiacci   +5 more
wiley   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source