Results 141 to 150 of about 187,335 (337)
Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent
ChemMedChem, Accepted Article.A triplex‐forming oligonucleotide (TFO) can form a sequence‐specific triple helix via Hoogsteen hydrogen bonding to polypurine tracts within a major groove side of a DNA duplex. Triplex formation can induce a double‐strand break, and this phenomenon at the amplified gene loci can selectively induce the cell death of cancer cells with specific gene ...
Haruki Toyama +5 more
wiley +1 more source
Gene Expression Analysis of HPRT-Deficient Cells Maintained with Physiological Levels of Folic Acid
CellsLesch–Nyhan disease (LND) is associated with a complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity due to mutations in the HPRT1 gene.
Rosa J. Torres +4 more
doaj +1 more source
Natural Configuration of the Purine Nucleotides in Ribonucleic Acids: Enzymatic Splitting of Purine Internucleotide Linkages [PDF]
, 1953 Leon Heppel, Roy Markham, R.J. Hilmoe
openalex +1 more source
Electron Transport Bilayer Design for Perovskite‐Based Tandem Solar Cells Using Thermal Evaporation
Chemistry–Methods, EarlyView.We provide a comprehensive explanation of designing a bi‐layer electron transport layer with a fullerene layer using the evaporation method in inverted perovskite solar cells (PSCs) and perovskite‐based tandem solar cells (PTSCs). Furthermore, we provide candidate materials for a bi‐layer and suggest a fullerene/SnO2 bi‐layer configuration for high ...
Siwon Yun +6 more
wiley +1 more source
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Science, 2016 I. Ben-Sahra +4 more
semanticscholar +1 more source
Drug Testing and Analysis, EarlyView.The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt +5 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy +3 more
wiley +1 more source
Metabolic changes during cardiac regeneration in the axolotl
Developmental Dynamics, EarlyView.Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich +10 more
wiley +1 more source
Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides
Nature, 2020 Jianfeng Xu +8 more
semanticscholar +1 more source