Results 151 to 160 of about 148,463 (294)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia. [PDF]

Nat Metab
Stewart AE, Zachman DK, Castellano-Escuder P, Kelly LM, Zolyomi B, Aiduk MDI, Delaney CD, Lock IC, Bosc C, Bradley J, Killarney ST, Stuart JD, Grimsrud PA, Ilkayeva OR, Newgard CB, Chandel NS, Puissant A, Wood KC, Hirschey MD.   +18 more
europepmc   +1 more source

79 DEGRADATION OF PURINE NUCLEOSIDES BY MITOCHONDRIAL ENZYMES OF BOVINE LIVER [PDF]

, 1988
R. A. Lewis, Laura Link, Wilbert Chen
openalex   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice. [PDF]

J Cell Mol Med
Alagbe AE, Little-Ihrig L, Mutchler SM, Jackson EK, Novelli EM, Tofovic SP.   +5 more
europepmc   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

One-Carbon Metabolism and Midbrain Dopaminergic Cells in Lesch-Nyhan Disease. [PDF]

Mol Syndromol
Alsuwaidi S, Ernst C.
europepmc   +1 more source

Purin [PDF]

, 2019
openaire   +1 more source

Studies of Nucleosides and Nucleotides. XLIII, Purine Cyclonucleosides.(10). Optical Rotatory Dispersion and Circular Dichroism of Adenine 8-Cyclonucleosides

, 1971
Morio Ikehara, Masakatsu Kaneko, Yuji Nakahara, Shoji Yamada, Seiichi Uesugi   +4 more
openalex   +2 more sources

2‐Chloro‐2′ ‐deoxyadenosine (Cladribine) and its Analogues are Good Substrates and Potent Selective Inhibitors of Escherichia coli Purine‐Nucleoside Phosphorylase [PDF]

, 1995
Agnieszka Bzowska, Zygmunt Kazimierczuk
openalex   +1 more source