Results 151 to 160 of about 187,335 (337)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li   +12 more
wiley   +1 more source

PURINE FERMENTATION BY CLOSTRIDIUM CYLINDROSPORUM

open access: hybrid, 1956
Jesse C. Rabinowitz, H.A. Barker
openalex   +1 more source

Alcohol consumption and incident heart failure in men and women

open access: yesEuropean Journal of Heart Failure, EarlyView.
Alcohol consumption and incident heart failure (HF) in men and women. Abstract Aims Regular heavy alcohol consumption may lead to the development of alcohol‐related cardiomyopathy and symptomatic heart failure (HF) later in life. However, the dose–response relationship between alcohol consumption and risk for incident HF, and whether these associations
Hailun Qin   +3 more
wiley   +1 more source

Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: Identification of a novel citraconate‐mediated pathway

open access: yesEuropean Journal of Heart Failure, EarlyView.
Aims Although functional recovery of the failing heart with left ventricular assist device (LVAD) unloading can occur, the underpinning mechanism is unclear. We aimed to characterize the effect of myocardial biochemical effect of LVAD support in vivo and in vitro.
David M. Kaye   +15 more
wiley   +1 more source

ON THE UTILIZATION OF PURINES AND THEIR RIBOSE DERIVATIVES BY YEAST

open access: hybrid, 1951
Stanley E. Kerr   +2 more
openalex   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Overcoming Toxicity Barriers for Boosting Nisin Synthesis in Lactococcus lactis Strain via Adaptive Laboratory Evolution

open access: yesFood Chemistry International, EarlyView.
After adaptive laboratory evolution against nisin, improved nisin production and tolerance were found in the evolved strains. To reveal the advantages of the evolved strains, a systematic comparison was made between the starting strains and the domesticated strains in terms of their microscopic morphology, metabolomics, transcriptomics, and whole ...
Xinyue Liu   +7 more
wiley   +1 more source

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

open access: yesCell, 2020
M. Z. Cader   +21 more
semanticscholar   +1 more source

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang   +7 more
wiley   +1 more source

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