Results 161 to 170 of about 209,598 (340)

Trimeric Architecture Ensures the Stability and Biological Activity of the Calf Purine Nucleoside Phosphorylase: In Silico and In Vitro Studies of Monomeric and Trimeric Forms of the Enzyme [PDF]

, 2023
Alicja Dyzma, Beata Wielgus‐Kutrowska, Agnieszka Girstun, Zoe Jelić Matošević, Krzysztof Staroń, Branimir Bertoša, Joanna Trylska, Agnieszka Bzowska   +7 more
openalex   +1 more source

A New View into the Regulation of Purine Metabolism: The Purinosome.

TIBS -Trends in Biochemical Sciences. Regular ed, 2017
Anthony M. Pedley, S. Benkovic
semanticscholar   +1 more source

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

Cell, 2020
M. Z. Cader, Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, M. N. Md-Ibrahim, S. Reikine, G. Sirago, L. Unger, Ana Belén Iglesias-Romero, K. Ramshorn, L. Haag, S. Saveljeva, J. Ebel, P. Rosenstiel, N. Kaneider, James C. Lee, T. Lawley, A. Bradley, G. Dougan, Y. Modis, Julian L. Griffin, A. Kaser   +21 more
semanticscholar   +1 more source

HMGB1 Assists in Overcoming Cisplatin Resistance in Chemoresistant Human Ovarian Cancer Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of ovarian cancer. However, the frequent development of cisplatin resistance remains a significant limitation, leading to therapeutic failure and poor patient outcomes.
Van Huynh, Guliang Wang, Anirban Mukherjee, Karen M. Vasquez   +3 more
wiley   +1 more source

New Pyrrolo[2,1-f]purine-2,4-dione and Imidazo[2,1-f]purine-2,4-dione Derivatives as Potent and Selective Human A₃ Adenosine Receptor Antagonists

, 2005
Pier Giovanni Baraldi, Delia Preti, Mojgan Aghazadeh Tabrizi, Francesca Fruttarolo, Romeo Romagnoli, Naser Abdel Zaid, Allan R. Moorman, Stefania Merighi, Katia Varani, Pier Andrea Borea   +9 more
openalex   +1 more source

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Metabolomic Signatures of Recovery: A Secondary Analysis of Public Longitudinal LC-MS Datasets Shows Polyphenol-Rich Interventions Attenuate Purine Degradation and Oxidative Stress Following Exhaustive Exercise. [PDF]

Metabolites
Wang X, Liu C, Chen Y, Wang M, Zhao K, Jiang W.   +5 more
europepmc   +1 more source

STUDIES ON ANALOGS OF PURINES AND PYRIMIDINES [PDF]

, 1950
George H. Hitchings, Gertrude B. Elion, Elvira A. Falco, Peter B. Russell, Henry Vanderwerff   +4 more
openalex   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli. [PDF]

PLoS Pathog
Zhang C, Yang Y, Wang S, Liu Y, Zhao X, Yin F, Hu Y, Xue Y, Bu Z, Li S, Tan C, Zhou R, Huang Q.   +12 more
europepmc   +1 more source