Results 161 to 170 of about 311,690 (329)

4‐Dimethylamino‐1,8‐Naphthalimide as a Fluorescence Signal Amplification for Site Selective and in Situ Probing of the Hydroxyl Radical

Chemistry – A European Journal, EarlyView.
4‐dimethylamino‐1,8‐naphthalimide (NMI) as new fluorescence‐responsive tool for HO• detection. Proof of concept illustrating that NMI selectively probes HO• produced by Cu‐bound to Aβ16 in presence of scavengers with an amplified response. Abstract Overproduction of reactive oxygen species (ROS) is involved in several diseases.
Yelisetty Venkata Suseela, Sabyasachi Mandal, Denis Jacquemin, Thimmaiah Govindaraju, Peter Faller   +4 more
wiley   +1 more source

Insights into the Molecular Mechanisms of Purine Compounds Synergistically Inducing Larval Settlement in Mytilopsis sallei Using Multi-Group Comparative Transcriptomic Analysis

Biology
Most benthic marine invertebrates exhibit a characteristic biphasic life cycle, consisting of a planktonic larval stage followed by a benthic adult stage [...]
Jian He, Huanhuan Hao, Huakang Pan, Shanshan Yao, Yiran Zhao, Shifeng Guo, Jianfang Huang, Danqing Feng   +7 more
doaj   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

Chemistry – A European Journal, EarlyView.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren   +4 more
wiley   +1 more source

Purine but Not Pyrimidine De Novo Nucleotide Biosynthesis Inhibitors Strongly Enhance the Antiviral Effect of Corresponding Nucleobases Against Dengue Virus [PDF]

Laurent Bonnac, Christine D. Dreis, Madhu Rai, Robert J. Geraghty   +3 more
openalex   +1 more source

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Science, 2016
I. Ben-Sahra, G. Hoxhaj, S. Ricoult, J. Asara, B. Manning   +4 more
semanticscholar   +1 more source

Acyclic Nucleoside Phosphonates As Potential Inhibitors Of Plasmodium Falciparum Egress

Chemistry – A European Journal, EarlyView.
Exploration of the chemistry of acyclic nucleoside phosphonates allowed us to study structural diversity from the hit compound; biological evaluation and molecular docking were performed to decipher key interactions with the putative target. Abstract The emergence of drug‐resistant Plasmodium strains requires the development of novel antimalarial ...
Thomas Cheviet, Sharon Wein, Corinne Lionne, Yan Badji, Natacha Venturini, Rachel Cerdan, Suzanne Peyrottes   +6 more
wiley   +1 more source

Development of Synthetic Routes to 2′‐O,4′‐C‐Spirocyclopentylene‐Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine

Chemistry – A European Journal, EarlyView.
A novel synthetic route to 2′‐O,4′‐C‐spirocyclopentylene‐bridged nucleic acid (scpBNA2) monomers bearing thymine, guanine, and adenine nucleobases. The strategy integrates 2′,4′‐lactonization, transglycosylation, and intramolecular iodocyclization, thereby bypassing the 2′‐OH inversion step and providing scpBNA2 nucleoside building blocks for antisense
Riku Kumagai, Riko Yamada, Takao Yamaguchi, Satoshi Obika   +3 more
wiley   +1 more source

Purines and Carotid Body: New Roles in Pathological Conditions [PDF]

, 2017
Sílvia V. Conde, Emília C. Monteiro, Joana F. Sacramento   +2 more
openalex   +1 more source

Neurologic Status of Patients With Purine Nucleoside Phosphorylase Deficiency Before and After Hematopoetic Stem Cell Transplantation [PDF]

, 2023
Betül Gemici Karaaslan, Isılay Turan, Sezin Aydemir, Zeynep Meric, Didem Atay, Arzu Akçay, Aysun Ayaz Sarı, Michael S. Hershfield, Funda Çipe, Başak Adaklı Aksoy, Gizem Zengin Ersoy, Ceyhun Bozkurt, Yasemin Kendir Demirkol, Gülyüz Öztürk, Çiğdem Aydoğmuş, Ayça Kıykım, Haluk Çokuğraş   +16 more
openalex   +1 more source

Design and Evaluation of Sticky End‐Type Bivalent DNA Aptamers Containing M08s‐1 as Anticoagulant Agents

ChemMedChem, EarlyView.
Sticky end‐type antithrombin aptamer, composed of two short hybridizable segments, is developed as a potential alternative to conventional anticoagulant drugs. The obtained bivalent aptamer surpasses existing long bivalent aptamers in anticoagulant activity and serum stability, offering advantages in synthesis efficiency and cost‐effectiveness. Aptamer
Maasa Yokomori, Mizuki Murasawa, Muneyuki Matsuo, Masanobu Nagano, Keitaro Yoshimoto   +4 more
wiley   +1 more source