Results 191 to 200 of about 311,690 (329)

Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming

Food Frontiers, EarlyView.
This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu, Sifan Guo, Dandan Xie, Zhibo Wang, Ying Cai, Xian Wang, Qiang Yang, Chunsheng Lin, Hong Yao, Qiqi Zhao, Yu Guan, Songqi Tang, Yiqiang Xie, Aihua Zhang   +13 more
wiley   +1 more source

Bifidobacterium longum subsp. longum CCFM1375 Mitigates Chronic Kidney Disease Progression via Gut Microbiota Modulation and Gut Barrier Restoration

Food Frontiers, EarlyView.
(1) Bifidobacterium longum subsp. longum CCFM1375 restored gut barrier integrity by upregulating ZO‐1/ZO‐2 and suppressing IL‐6/TNF‐α, thereby reducing serum LPS and improving creatinine/BUN levels. (2) Reshaped gut microbiota: enriched beneficial species (Faecalibaculum rodentium, Asaccharobacter celatus, Adlercreutzia equolifaciens) while suppressing
Hongchao Wang, Xinchen Lv, Yue Zhang, Jinlin Zhu, Jia Hua, Bin Liu, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu, Zhijian Zhang, Liang Wang   +11 more
wiley   +1 more source

Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments. [PDF]

Eur J Med Res
Zeng Y, Hu J, Lu J, Zhu Y.
europepmc   +1 more source

Medicine‐Food Plant Polysaccharides Modulate Diabetes and Diabetic Complications Through Maintaining Gut Function: A Review

Food Frontiers, EarlyView.
Polysaccharides derived from medicine‐food plants restore intestinal barrier integrity and microbiota balance while modulating short‐chain fatty acid levels. These modifications significantly alleviate diabetes and its complications, including nephropathy, retinopathy, cardiovascular disease, and neuropathy.
Yi Long, Wanglong Yu, Pingping Yang, Minxuan Xu, Jitao Ling, Yuting Wu, Xiao Liu, Liu Ouyang, Yan Xiong, Jianping Liu, Yiming Gan, Jing Zhang, Peng Yu, Deju Zhang   +13 more
wiley   +1 more source

Comparison of the total and individual purine content of commercial maintenance dog foods and therapeutic dog foods that may be prescribed to prevent urate urolithiasis. [PDF]

BMC Vet Res
Ishii CS, Scott KC, Abrahan C, Harmon TA, Colee JC, Queau Y, Biourge V, Garrett TJ, Hill RC.   +8 more
europepmc   +1 more source

Tea and Blood–Brain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies

Food Frontiers, EarlyView.
Abstract The blood–brain barrier (BBB), a selective interface regulating cerebral substance exchange, plays a crucial role in maintaining cognitive function and metabolic balance. While tea consumption has been traditionally associated with health benefits, its specific effects on BBB integrity warrant systematic investigation. This review demonstrates
Rongbosen Yue, Haitao Wen, Lian He, Yan Liu, Zeng Liang, Liyong Luo   +5 more
wiley   +1 more source

Plantagoside Alleviate Hepatic Inflammation, Oxidative Stress and Histopathological Damage in D-Galactose-Induced Senescent Mice by Modulating Purine Metabolic Pathways. [PDF]

Food Sci Nutr
Liu J, Zhang Y, Lv F, Wang C, Wang J, Li L, Wu J, Lai L.   +7 more
europepmc   +1 more source

Purine metabolism in cultured endothelial cells [PDF]

, 1980
Gerbes, Alexander L., Gerlach, E., Nees, S., Sperling, Oded, Willershausen, B.   +4 more
core   +1 more source

Crystal and molecular structure of kinetin picrate: a novel compound containing an N(3)H and N(7)H tautomeric form of purine [PDF]

, 1984
M. Soriano-Garcı́a, Rubén A. Toscano
openalex   +1 more source

Application of Surface‐Enhanced Raman Spectroscopy (SERS) in Histamine Analysis of Aquatic Products: Principles, Applications, Challenges, and Prospects

Food Frontiers, EarlyView.
This review introduces the significant advantages of SERS detection of histamine, which is accurate, non‐destructive, and fast. By critically analyzing the current challenges, we propose future directions for industrializing the application of SERS in histamine detection.
Xingying Jiang, Ruizhi Yang, Jia Liang, Bin Zheng, Meiling Chen, Bin Zhang, Tao Han, Yadong Zhao, Soottawat Benjakul   +8 more
wiley   +1 more source