Glutathione-Mediated Neuroprotective Effect of Purine Derivatives. [PDF]
Int J Mol Sci, 2023 Numerous basic studies have reported on the neuroprotective properties of several purine derivatives such as caffeine and uric acid (UA). Epidemiological studies have also shown the inverse association of appropriate caffeine intake or serum urate levels with neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson’s disease (PD).
Matsumura N, Aoyama K.
europepmc +5 more sources
Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia [PDF]
Pharmaceutics, 2022 We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases.
Jeanluc Bertrand +10 more
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Thermoanalytical study of purine derivatives compounds
Eclética Química, 2018 Thermal methods of analysis are now used in a very large range of scientific investigations. In this work simultaneous thermogravimetry-differential thermal analysis (TG-DTA), X-Ray powder diffractometry and infrared spectroscopy were used to study the ...
G. F. C. Sotelo +2 more
doaj +7 more sources
Purine-based chemical probe with HOMO switching for intracellular detection of mercury ions [PDF]
Scientific ReportsThe detailed photophysical characterization of 2-piperidinyl-6-triazolylpurine derivatives and their complexes with metal ions is presented. The studied compounds contain two electron donating units – piperidine and methoxyphenyl, while triazolyl-purine ...
Kamilė Boguševičienė +11 more
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Molecules, 2023 Synthetic unnatural base pairs have been proven to be attractive tools for the development of DNA-based biotechnology. Our group has very recently reported on alkynylated purine–pyridazine pairs, which exhibit selective and stable base-pairing via ...
Hidenori Okamura +4 more
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Total synthesis of [15N]-labelled C6-substituted purines from [15N]-formamide—easy preparation of isotopically labelled cytokinins and derivatives [PDF]
Royal Society Open Science, 2018 Cytokinins (CKs) and their metabolites and derivatives are essential for cell division, plant growth regulation and development. They are typically found at minute concentrations in plant tissues containing very complicated biological matrices. Therefore,
Jan Buček +7 more
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The effects of seasonal variation on the microbial-n flow to the small intestine and prediction of feed intake in grazing karayaka sheep [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2013 The objectives of the present study were to estimate the microbial-N flow to the small intestine and to predict the digestible organic matter intake (DOMI) in grazing Karayaka sheep based on urinary excretion of purine derivatives (xanthine, hypoxanthine,
SALMAN M, CETINKAYA N, SELCUK Z, GENC B
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Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]
, 2013 Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Fürst, Robert +8 more
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Scientific African, 2020 The corrosion inhibition potential of purine and its twelve derivatives was theoretically investigated. Their chemical descriptors: dipole moments, softness, electronegativity, chemical hardness, molecular weight in conjunction with the electronic ...
B.T. Ogunyemi, D.F. Latona, I.A. Adejoro
doaj +1 more source
Rocaglates induce gain-of-function alterations to eIF4A and eIF4F [PDF]
, 2020 Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies.
Baranov, Pavel V. +12 more
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