Long‐term remission in gout: Challenges and future opportunities
Rheumatology &Autoimmunity, EarlyView.Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley +1 more source
Effect of corn supplementation on purine derivatives and rumen fermentation in sheep fed PKC and urea-treated rice straw. [PDF]
Trop Anim Health Prod, 2018 Saeed OA +4 more
europepmc +1 more source
Rheumatology &Autoimmunity, EarlyView.Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen +6 more
wiley +1 more source
Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2
Rheumatology &Autoimmunity, EarlyView.Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li +5 more
wiley +1 more source
Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
VIEW, EarlyView.This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li +5 more
wiley +1 more source
Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells. [PDF]
Molecules, 2018 Bosco B +9 more
europepmc +1 more source
Below‐ground drivers of rhizosphere functional gene assembly during Moso bamboo expansion
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Moso bamboo (Phyllostachys edulis) expansion threatens subtropical forest biodiversity, yet how intraspecific root trait variation shapes rhizosphere microbial functional potential remains unclear.
Yaoxing Wu +8 more
wiley +1 more source
Microwave assisted synthesis of coumarin-purine derivatives: An approach to in vitro anti-oxidant, DNA cleavage, crystal structure, DFT studies and Hirshfeld surface analysis. [PDF]
Heliyon, 2019 Mangasuli SN, Hosamani KM, Managutti PB.
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Biosynthesis of purine derivatives in young wheat plants
Acta Societatis Botanicorum Poloniae, 2015 H. Rybicka
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BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To quantify the transplacental transfer of aciclovir at an amount equivalent to 2 g of valaciclovir corresponding to the fractionated dosing regimen given four times daily used to reduce congenital cytomegalovirus (CMV) transmission and to treat the CMV‐infected fetus. Design Experimental ex vivo study.
Helyett Ollivier +9 more
wiley +1 more source