Results 141 to 150 of about 72,751 (304)

Integrated multi‐biofluid extracellular vesicle isolation with dual‐platform mass spectrometry metabolomics for prostate cancer detection

VIEW, EarlyView.
Abstract Prostate cancer poses a significant clinical challenge due to limited screening methods and incomplete understanding of its metabolic rewiring. Extracellular vesicles (EVs) carry bioactive metabolites that mirror tumor biology, enabling mechanistic study and biomarker discovery.
Chengbang Wang, Xueying Chen, Xuhong Zhang, Xianqi Shen, Haisong Tan, Yanbo Chen, Shaohua Chen, Shilong Liu, Xu Gao, Fubo Wang, Shunxiang Li, Bin Xu   +11 more
wiley   +1 more source

Peptide nucleic acid biosensors: Structure–interface interactions, electrochemical signal strategies, and diagnostic applications

VIEW, EarlyView.
This review discusses the structural and functional properties of peptide nucleic acid (PNA)‐based biosensors, emphasizing their sensitivity, enzymatic resistance, and diagnostic potential. It presents a comparative analysis of detection limits across sensor designs, focusing on probe immobilization, electrode composition, and signal amplification. The
Younghwan Kim, Swomitra Kumar Mohanty
wiley   +1 more source

Purine metabolism: a pan-cancer metabolic dysregulation across circulation and tissues. [PDF]

Mol Cancer
Yu M, Liu C, Cao M, Yang D, Wang T, Xu J, Zhu D, Wang G, Aa J, Zhu W.   +9 more
europepmc   +1 more source

Nutritional approach in a growing Jack Russell terrier with gall bladder agenesis

Veterinary Record Case Reports, EarlyView.
Abstract An asymptomatic male Jack Russell terrier diagnosed at the age of 18 weeks with congenital gall bladder agenesis, confirmed by computed tomography scan, after finding abnormally high values for liver enzymes in a routine blood count. Treatment with liver‐protective agents S‐adenosylmethionine and ursodeoxycholic acid was initiated. At 6 months
Tamara Seghers, Matthias Dennler, Brigitta Wichert, Annette Liesegang   +3 more
wiley   +1 more source

Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism. [PDF]

Acta Physiol (Oxf)
Byrne NJ, Koentges C, Pfeil K, Lueg JC, Bakshi S, Tarkhnishvili A, Vosko I, Gollmer J, Birkle LC, Rathner T, Birkle S, Tang S, Rau C, Hoffmann MM, Odening KE, Barnes S, Wilson LS, Ljubojevic-Holzer S, Wallner M, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Wende AR, Zirlik A, Bugger H.   +26 more
europepmc   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

Supplementary Figure 5 from One-Carbon Metabolism Inhibition Depletes Purines and Results in Profound and Prolonged Ewing Sarcoma Growth Suppression

Sara Zirpoli, Noah Copperman, Shrey Patel, A.R.W. Forrest, Zhanjun Hou, Larry H. Matherly, David M. Loeb, Antonio Di Cristofano   +7 more
openalex   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Purine Metabolism and Dystonia: Perspectives of a Long-Promised Relationship. [PDF]

Ann Neurol
Sorrentino U, O'Neill AG, Kollman JM, Jinnah HA, Zech M.   +4 more
europepmc   +1 more source

Integrated Bioinformatics and Multi-Omics Reveal the Molecular Mechanism of Astragalus  Aqueous Extract in Treating Hyperuricemic Nephropathy Via Gut–Kidney Axis-Mediated Purine Metabolism Regulation

Tingli Qu, Nan Zhang, Junjie Cai, Chen Li, Yue Zhang, Xinxue Xu, Shuai Zhang, Weilin Lv, Taigang Liang   +8 more
openalex   +1 more source