Results 141 to 150 of about 1,394,357 (370)

Multi-omics analyses reveal interactions between the skin microbiota and skin metabolites in atopic dermatitis

Frontiers in Microbiology
IntroductionAtopic dermatitis (AD) is one of the most common inflammatory skin diseases. Skin microecological imbalance is an important factor in the pathogenesis of AD, but the underlying mechanism of its interaction with humans remains unclear ...
Kaikai Huang, Fang Li, Yingyao Liu, Baoying Liang, Pinghua Qu, Linlin Yang, Shanshan Han, Wenjun Li, Xiumei Mo, Xiumei Mo, Xiumei Mo, Lei Dong, Ying Lin, Ying Lin, Ying Lin   +14 more
doaj   +1 more source

The Link between Purine Metabolism and Production of Antibiotics in Streptomyces

Antibiotics, 2019
Stress and starvation causes bacterial cells to activate the stringent response. This results in down-regulation of energy-requiring processes related to growth, as well as an upregulation of genes associated with survival and stress responses. Guanosine
Smitha Sivapragasam, A. Grove
semanticscholar   +1 more source

Jia Wei Xiao Yao San ameliorates chronic stress-induced depression-like behaviors in mice by regulating the gut microbiome and brain metabolome in relation to purine metabolism

, 2022
Shuai Ji, Shuangshuang Han, Lin Yu, Lijing Du, Yanting You, Jieyu Chen, Ming Wang, Shengwei Wu, Shasha Li, Xiaomin Sun, Ren Luo, Xiaoshan Zhao   +11 more
openalex   +1 more source

Protective Effects of Auricularia auricula Polysaccharides on Acute Lung Injury by Regulating Intestinal Flora and Metabolism

Food Frontiers, EarlyView.
Auricularia auricula polysaccharides (AAP; 100, 200, and 400 mg/kg) protect against acute lung injury (ALI) by dose‐dependently remodeling the gut microbiota and modulating associated metabolic pathways via the gut‐lung axis, thereby enhancing pulmonary anti‐inflammatory and antioxidant capacity to ultimately prevent tissue damage.
Haili Niu, Fangjia Zhao, Qi Wang, Min Li, Yuan Li, Ivan Kurtovic, Zitong Zhang, Yahong Yuan, Tianli Yue   +8 more
wiley   +1 more source

Metabolic Profiling of Non-volatile Compounds during Xinyang Maojian Tea Processing Using Untargeted Metabolomics [PDF]

Shipin Kexue
In order to understand the dynamic changes of non-volatile metabolites in Xinyang Maojian tea during processing, Xinyang Maojian tea samples from Xinyang tea population (Camellia sinensis cv.
KONG Yashuai, CHEN Lingzhi, CHENG En, ZHU Yao, WANG Jingjing, WANG Xiao, WANG Zihao, CHEN Yi, YIN Peng, GUO Guiyi
doaj   +1 more source

Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Idiopathic inflammatory bowel disease (IBD) is associated with the gut microbiota and immune system of the host; however, the precise pathogenesis of IBD is poorly defined.
Y. Nagahama, Mayuko Shimoda, Guoliang Mao, Shailendra Kumar Singh, Yuuki Kozakai, Xin-hua Sun, D. Motooka, S. Nakamura, Hiroki Tanaka, T. Satoh, K. Maeda, S. Akira   +11 more
semanticscholar   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, EarlyView.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Effects of Different Packaging on the Purine Content and Key Enzymes of Refrigerated Yellow Croaker (Larimichthys crocea)

Foods
In this study, we investigated the effects of air packaging, vacuum packaging and modified atmosphere packaging (CO2/N2: 80/20) on the purine metabolism and enzyme activities of refrigerated large yellow croakers.
Tiansheng Xu, Wenxuan Lu, Bohan Chen, Dapeng Li, Jing Xie   +4 more
doaj   +1 more source

High fludarabine exposure and relationship with treatment-related mortality after nonmyeloablative hematopoietic cell transplantation. [PDF]

, 2011
Despite its common use in nonmyeloablative preparative regimens, the pharmacokinetics of fludarabine are poorly characterized in hematopoietic cell transplantation (HCT) recipients and exposure-response relationships remain undefined.
Brunstein, CG, Cao, Q, Green, KG, Jacobson, PA, Long-Boyle, JR, McGlave, PB, Miller, JS, Rogosheske, J, Wagner, JE, Weisdorf, DJ   +9 more
core   +1 more source