Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments [PDF]
European Journal of Medical ResearchObjective Metabolomics analyses suggest abnormal purine metabolism during the development of osteoporosis. This study aimed to investigate the role of purine metabolism-related genes in osteoporosis.
Yuqing Zeng +3 more
doaj +2 more sources
The impact of bacterial purine metabolism on antibiotic efficacy [PDF]
npj Antimicrobials and ResistanceMetabolism plays a key role in the three antibiotic evasion strategies used by bacteria: tolerance, persistence and resistance. Modulation of purine metabolism is emerging as a common, and clinically relevant, contributor to tolerant and resistant ...
Claire E. Stevens +2 more
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Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin +9 more
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A circular network of purine metabolism as coregulators of dilated cardiomyopathy
Journal of Translational Medicine, 2022 Background The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic environment stability, but disorganized mechanics of with respect to developing heart failure (HF) is ...
Ge Wang +7 more
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Rewiring of purine metabolism in response to acidosis stress in glioma stem cells [PDF]
Cell Death and Disease, 2021 Glioma stem cells (GSCs) contribute to therapy resistance and poor outcomes for glioma patients. A significant feature of GSCs is their ability to grow in an acidic microenvironment.
Xiaoyu Xu +11 more
semanticscholar +2 more sources
Cell Death and DiseaseOsteoporosis is a major degenerative metabolic bone disease that threatens the life and health of postmenopausal women. Owing to limitations in detection methods and prevention strategy awareness, the purpose of osteoporosis treatment is more to delay ...
Keda Yang +4 more
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Yeast to Study Human Purine Metabolism Diseases
Cells, 2019 Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences.
Bertrand Daignan-Fornier, Benoît Pinson
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Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Nature Communications, 2020 Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by
Weihua Zhou +27 more
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Purine metabolism in lung adenocarcinoma: A single-cell analysis revealing prognostic and immunotherapeutic insights. [PDF]
J Cell Mol MedLung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer, yet the contribution of purine metabolism (PM) to its pathogenesis remains poorly elucidated.
Zhang P +5 more
europepmc +2 more sources
Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis [PDF]
Molecular OncologyColorectal cancer (CRC) is widely recognized for its high prevalence and significant mortality rates, and purine metabolism has been serving as a potential therapeutic target.
Sungyeon Kim +8 more
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