Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma
Molecular & Cellular Oncology, 2020 Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma.
Weihua Zhou, Daniel R Wahl
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Yeast to Study Human Purine Metabolism Diseases
Cells, 2019 Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences.
Bertrand Daignan-Fornier, Benoît Pinson
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Disorders of purine biosynthesis metabolism.
Molecular Genetics and Metabolism, 2021 Purines are essential molecules that are components of vital biomolecules, such as nucleic acids, coenzymes, signaling molecules, as well as energy transfer molecules. The de novo biosynthesis pathway starts from phosphoribosylpyrophosphate (PRPP) and eventually leads to the synthesis of inosine monophosphate (IMP) by means of 10 sequential steps ...
J. Dewulf, S. Marie, M. Nassogne
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Purine metabolism regulates Vibrio splendidus persistence associated with protein aggresome formation and intracellular tetracycline efflux [PDF]
Frontiers in Microbiology, 2023 A small subpopulation of Vibrio splendidus AJ01 that was exposed to tetracycline at 10 times the minimal inhibitory concentration (MIC) still survived, named tetracycline-induced persister cells in our previous work.
Yanan Li +5 more
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Purine Metabolism and Rett Syndrome
Pediatric Neurology Briefs, 1996 Levels of purine and pyridine nucleotides and their metabolites were determined in erythrocytes and plasma of 31 Rett pattients and 17 age-matched controls at the Departments of Molecular Biology and Child Psychiatry, University of Siena, Children’s ...
J Gordon Millichap
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Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis [PDF]
Cell Death and DiseaseOsteoporosis is a major degenerative metabolic bone disease that threatens the life and health of postmenopausal women. Owing to limitations in detection methods and prevention strategy awareness, the purpose of osteoporosis treatment is more to delay ...
Keda Yang +4 more
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Purine Metabolism in Acute Cerebral Ischemia
Общая реаниматология, 2008 Objective: to study the specific features of purine metabolism in clinically significant acute cerebral ischemia. Subjects and materials. Three hundred and fifty patients with the acutest cerebral ischemic stroke were examined.
Ye. V. Oreshnikov +2 more
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Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment [PDF]
Advanced ScienceSmall colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms.
Tingwang Shi +11 more
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Purine metabolism-related genes and immunization in thyroid eye disease were validated using bioinformatics and machine learning [PDF]
Scientific Reports, 2023 Thyroid eye disease (TED), an autoimmune inflammatory disorder affecting the orbit, exhibits a range of clinical manifestations. While the disease presentation can vary, cases that adhere to a prototypical pattern typically commence with mild symptoms ...
Zixuan Wu +4 more
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