Results 231 to 240 of about 72,751 (304)

Exploration of the mutational landscape of cutaneous leiomyoma confirms FH as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy. [PDF]

Br J Dermatol
van der Weyden L, Del Castillo Velasco-Herrera M, Cheema S, Wong K, Boccacino JM, Vermes I, Offord V, Droop A, Jones DRA, Anderson E, Hardy C, de Saint Aubain N, Ferguson PM, Mogler C, Rajan N, Frew D, Harms PW, Billings SD, Schatton D, Segarra-Mondejar M, Arends MJ, Ferreira I, Brenn T, Frezza C, Adams DJ.   +24 more
europepmc   +1 more source

The optimization of crop response to climatic stress through modulation of plant stress response mechanisms. Opportunities for biostimulants and plant hormones to meet climate challenges.

New Phytologist, Volume 249, Issue 1, Page 130-151, January 2026.
Summary This review discusses the use of agronomic management practices to enhance crop stress resilience to climate stress through the modulation of natural plant growth regulatory pathways. The use of biostimulants or plant hormones to improve crop resilience is subject to strict regulatory oversight if changes in the regulation of plant growth are ...
Jing Li, Giulia Forghieri, Danny Geelen, Patrick du Jardin, Patrick H. Brown   +4 more
wiley   +1 more source

Interaction of Tri-Cyclic Nucleobase Analogs with Enzymes of Purine Metabolism: Xanthine Oxidase and Purine Nucleoside Phosphorylase. [PDF]

Int J Mol Sci
Stachelska-Wierzchowska A, Narczyk M, Wierzchowski J, Bzowska A, Wielgus-Kutrowska B.   +4 more
europepmc   +1 more source

Stress Nutrition in Aquatic Animals: From Definition to Practice

Reviews in Aquaculture, Volume 18, Issue 1, January 2026.
ABSTRACT Aquaculture faces numerous challenges, with stress being one of the major issues that lead to growth loss, metabolic disorders, weakened immunity, redox imbalance, and organ damage in aquatic animals. Nutritional intervention is one of the effective strategies to address these problems. Traditional research has primarily focused on the impacts
Jian Zhang, Qianwen Ding, Ruobing Lou, Yuanpei Zhang, Yuanyuan Yao, Yalin Yang, Zhen Zhang, Chao Ran, Zhigang Zhou   +8 more
wiley   +1 more source

Characterization of Inosine triphosphate pyrophosphatase, an important protein involved in purine metabolism

, 2015
Sam Björklund
openalex   +1 more source

From MS1 to Structure: A Van Krevelen–DBE–Aromaticity‐Based Framework for Annotating Specialized Metabolites via High‐Resolution Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 39, Issue 24, 30 December 2025.
ABSTRACT Rationale Classifying specialized metabolites in untargeted metabolomics remains a major challenge, particularly when relying solely on high‐resolution mass spectrometry (HRMS) data at the MS1 level. Traditional approaches using Van Krevelen diagrams often lack sufficient resolution to distinguish structurally similar metabolite classes ...
Nerilson M. Lima, Luana A. Pereira, Lucas S. Tironi, Matheus P. G. do Carmo, Milbya L. Costa, Renato A. Oliveira, Salva Asghar, Vinicius Fortes da Silva   +7 more
wiley   +1 more source

Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis. [PDF]

Cells
Worledge CS, Kostelecky RE, Zhou L, Bhagavatula G, Colgan SP, Lee JS.   +5 more
europepmc   +1 more source

Short‐Term Alcohol Consumption Is Sufficient to Disrupt Microbial Communities and the Intestinal and Circulating Metabolites in a Non‐Human Primate Model

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
This study assessed the impact of short‐term (6 months) voluntary ethanol self‐administration on the composition of the gut microbiome as well as fecal and circulating metabolomes using a non‐human primate model. We demonstrate that short‐term ethanol consumption increased the abundance of microbes associated with inflammation resolution, while ...
Madison B. Blanton, Ethan G. Napier, Katelyn E. Keen, Ethan V. Stuart, Isaac R. Cinco, Hami Hemati, Ronald C. Bruntz, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi   +9 more
wiley   +1 more source

De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression. [PDF]

Cancer Res Commun
Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM.   +18 more
europepmc   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source