Results 241 to 250 of about 1,297,457 (342)

Pioglitazone-induced alterations of purine metabolism in healthy male subjects. [PDF]

Clin Transl Sci
Kang J, Li Y, Lee S, Yu KS, Cho JY.
europepmc   +1 more source

Resistance to TRAIL in mantle cell lymphoma cells is associated with the decreased expression of purine metabolism enzymes

, 2013
Jana Pospíšilová, Ondřej Vít, Lucie Lorková, Magdalena Klánová, J Živný, Pavel Klener, Jir̆ı́ Petrák   +6 more
openalex   +2 more sources

Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats

Experimental Physiology, EarlyView.
Abstract Physical exercise promotes brain health and cognitive function possibly through mechanisms that include strengthened resistance to oxidative stress. However, limited research has explored the cumulative effects of regular voluntary exercise on both oxidative stress and defence mechanisms in hippocampus and cortex, two regions essential for ...
Camilla Myrup Holst, Iria Esperon‐Abril, Frederik Bryske Juhl, Jesper Emil Jakobsgaard, Jonas B. Kristiansen, Kristian Vissing, Tinna Stevnsner   +6 more
wiley   +1 more source

Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to purine metabolism-associated genes. [PDF]

Sci Rep
Liang F, Zheng M, Lu J, Liu P, Chen X.
europepmc   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Striatal Neurodevelopment Is Dysregulated in Purine Metabolism Deficiency and Impacts DARPP-32, BDNF/TrkB Expression and Signaling: New Insights on the Molecular and Cellular Basis of Lesch-Nyhan Syndrome

, 2014
Ghiabe-Henri Guibinga, Nikki Barron, William Pandori   +2 more
openalex   +2 more sources

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

International Journal of Cancer, Volume 157, Issue 7, Page 1304-1315, 1 October 2025.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang, Steven C. Moore, Sheng Fu, Xiaoyu Wang, Demetrius Albanes, Stephanie J. Weinstein, Kai Yu, Rachael Z. Stolzenberg‐Solomon   +7 more
wiley   +1 more source

Conditional Stabilization of the Hypoxia‐Inducible Factor HIF1α— Photoswitchable Stapled Peptides Prevent Elongin BC–Mediated Degradation

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
Visible‐light photoswitchable peptides enable the stabilization of the hydroxylated hypoxia transcription factor 1α (HIF1α—OH) by targeting the pVHL‐EloBC interaction. Significant differences in conformation, binding, and transcription of HIF‐targeted genes between the photostationary states (PSS) were demonstrated.
Van Tuan Trinh, Sabrina Fischer, Lei Zhang, Heiko Geisler, Belen Pardo, Robert Liefke, Frank Abendroth, Olalla Vázquez   +7 more
wiley   +2 more sources

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer. [PDF]

Sci Signal
Cordova RA, Sommers NR, Law AS, Klunk AJ, Brady KE, Goodrich DW, Anthony TG, Brault JJ, Pili R, Wek RC, Staschke KA.   +10 more
europepmc   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source