Results 241 to 250 of about 61,638 (306)

Staphylococcus aureus mutants resistant to the feed-additive monensin show increased virulence and altered purine metabolism. [PDF]

mBio
Warsi OM, Upterworth LM, Breidenstein A, Lustig U, Mikkelsen K, Nagy T, Szatmari D, Ingmer H, Andersson DI.   +8 more
europepmc   +1 more source

Hyperbaric Pressures Enhance Antioxidant Enzyme Activity and Suppress Grey Mould in Débora Tomato Fruits

Plant Pathology, EarlyView.
Hyperbaric pressures reduced conidial germination, mycelial growth of Botrytis cinerea in vitro and increased the activity of antioxidant enzymes in tomatoes. ABSTRACT Hyperbaric pressures have been shown to be an efficient technique to inhibit physiological mechanisms of ripening, microbiological development and senescence in vegetables, prolonging ...
Vanessa Voigt Palaretti, Carlos Inestroza‐Lizardo, José Sidnaldo Pinzetta Junior, Ben‐Hur Mattiuzzo   +3 more
wiley   +1 more source

Ethanol Extracts from Torreya grandis Seed Have Potential to Reduce Hyperuricemia in Mouse Models by Influencing Purine Metabolism. [PDF]

Foods
Yao J, Bai E, Duan Y, Huang Y.
europepmc   +1 more source

Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats

Experimental Physiology, EarlyView.
Abstract Physical exercise promotes brain health and cognitive function possibly through mechanisms that include strengthened resistance to oxidative stress. However, limited research has explored the cumulative effects of regular voluntary exercise on both oxidative stress and defence mechanisms in hippocampus and cortex, two regions essential for ...
Camilla Myrup Holst, Iria Esperon‐Abril, Frederik Bryske Juhl, Jesper Emil Jakobsgaard, Jonas B. Kristiansen, Kristian Vissing, Tinna Stevnsner   +6 more
wiley   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, Volume 73, Issue 8, Page 1673-1691, August 2025.
Main Points Astroglial CB1 mediate long‐term depression in the NAc through purine release. Amphetamine occludes LTD in male mice by inducing the saturation of A1 receptors. Astroglial CB1 mediate behavioral amphetamine effects in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source

Trained Immunity Induced by Oxidized Low‐Density Lipoprotein Is Dependent on Glutaminolysis

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
A brief exposure to oxLDL induces a trained immunity phenotype in monocytes, characterized by increased cytokine production upon secondary LPS challenge. This enhanced proinflammatory phenotype is supported by increased glutaminolysis and elevated glutamate processing through the TCA cycle, as well as increased oxidative phosphorylation.
Alice Scarpa, Yerin Jung, Arslan Hamid, Vasiliki Matzaraki, Tushar More, Alexander Heinz, Laszlo Groh, Siroon Bekkering, Karsten Hiller, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek, Niels P. Riksen   +12 more
wiley   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Bioinformatic validation and machine learning-based exploration of purine metabolism-related gene signatures in the context of immunotherapeutic strategies for nonspecific orbital inflammation. [PDF]

Front Immunol
Wu Z, Fang C, Hu Y, Peng X, Zhang Z, Yao X, Peng Q.   +6 more
europepmc   +1 more source

Novel Data‐Driven Mechanistic Modeling of Untargeted Metabolome Data Reveals Feed Component Effects in CHO Cell Bioprocess Using Column Generation‐Based EFMs

Biotechnology Journal, Volume 20, Issue 7, July 2025.
Graphical Abstract and Lay Summary This study presents a novel approach for applying mechanistic metabolic modeling to untargeted metabolomics data from the production process of a difficult‐to‐express enzyme by CHO cells, to identify key feed media component candidates responsible for improved productivity through feed modification. The study analyzed
Meeri E.‐L. Mäkinen, Markella Zacharouli, Sigrid Särnlund, Yun Jiang, Veronique Chotteau   +4 more
wiley   +1 more source

Desorption Electrospray Ionization Mass Spectrometry Imaging Techniques Depict a Reprogramming of Energy and Purine Metabolism in the Core Brain Regions of Chronic Social Defeat Stress Mice. [PDF]

Metabolites
Song Y, Xiao F, Aa J, Wang G.
europepmc   +1 more source