Results 41 to 50 of about 1,297,457 (342)
Hepatology Communications, 2020 Tumor‐specific metabolic rewiring, acquired to confer a proliferative and survival advantage over nontransformed cells, represents a renewed focus in cancer therapy development.
Y. Chong +16 more
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Purine metabolism controls innate lymphoid cell function and protects against intestinal injury [PDF]
Immunology and Cell Biology, 2018 Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including IBD. However, the
Siobhan Crittenden +13 more
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Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism
Science Advances, 2020 An inflammatory mediator interrupts early steps in bacterial cell division by inhibiting nucleoside triphosphate synthesis. Cytostasis is the most salient manifestation of the potent antimicrobial activity of nitric oxide (NO), yet the mechanism by which
J. Jones-Carson +6 more
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ACS Synthetic Biology, 2020 Nucleosides and purine analogs have multiple functions in cell physiology, food additives, and pharmaceuticals, and some are produced on a large scale using different microorganisms. However, biosynthesis of purines is still lacking. In the present study,
Min Liu +4 more
semanticscholar +1 more source
Scientific Reports, 2020 Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the diversity of molecular ...
P. Hamilton +16 more
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Ecotoxicology and Environmental Safety, 2023 Cadmium (Cd) exposure has been associated with the development of enterohepatic circulation disorders and hyperuricemia, but the possible contribution of chronic low-dose Cd exposure to disease progression is still need to be explored.
Hui Zhang +11 more
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Purine metabolism in Echinococcus multilocularis
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1998 The activities of the enzymes in Echinococcus multilocularis metacestodes involved in purine salvage were studied by HPLC. As in most parasites, this cestode relies entirely on salvage of preformed bases and nucleosides for its purine requirement. Therefore, these enzymes may be targets for drugs in the chemotherapeutic treatment of diseases caused by ...
Anne-Françoise Pétavy +2 more
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Molecules, 2023 To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai +5 more
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The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto de vitto +3 more
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5′-Nucleotidase Plays a Key Role in Uric Acid Metabolism of Bombyx mori
Cells, 2021 Uric acid (UA) is the end-product in the human purine metabolism pathway. The UA that accumulates in silkworm tissues is excreted as a nitrogen waste product.
Linmeng Tang +11 more
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