Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase
Pharmaceutical and Biomedical Research, 2019 Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi +9 more
doaj
Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]
J Phys Chem B, 2023 Frost CF +3 more
europepmc +1 more source
Purine nucleoside phosphorylase deficiency associated with a fatal lymphoproliferative disorder. [PDF]
, 1981 Alan R. Watson +4 more
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The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a `spanner in the works'. [PDF]
Acta Crystallogr F Struct Biol Commun, 2022 Given FM +6 more
europepmc +1 more source
Investigation of α-deuterium kinetic isotope effects on the purine nucleoside phosphorylase reaction by the equilibrium-perturbation technique [PDF]
, 1989 Pertti Lehikoinen +2 more
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Control of ATP homeostasis during the respiro‐fermentative transition in yeast
Molecular Systems Biology, 2010 Respiring Saccharomyces cerevisiae cells respond to a sudden increase in glucose concentration by a pronounced drop of their adenine nucleotide content ([ATP]+[ADP]+[AMP]=[AXP]).
Thomas Walther +6 more
doaj +1 more source
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. [PDF]
, 1987 Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity ...
Carson, DA, Kornbluth, RS, Richman, DD
core
, 2017 Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer.
Agirre, Xabier +13 more
core +3 more sources
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. [PDF]
J Med Chem, 2023 Skácel J +21 more
europepmc +1 more source