Molecules, 2019 Purine isosteres present excellent opportunities in drug design and development. Using isosteres of natural purines as scaffolds for the construction of new therapeutic agents has been a valid strategy of medicinal chemistry.
Ahmad Junaid +4 more
doaj +1 more source
A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]
, 2001 Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren +4 more
core +1 more source
Uncovering the signaling pathway behind extracellular guanine-induced activation of NO System: New perspectives in memory-related disorders [PDF]
, 2018 Mounting evidence suggests that the guanine-based purines stand out as key player in cell metabolism and in several models of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases.
Belluardo, Natale +11 more
core +1 more source
Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency [PDF]
, 1978 Amos Cohen +4 more
openalex +1 more source
Purine Nucleoside Phosphorylase from Escherichia coli and Salmonella typhimurium [PDF]
, 1975 Kaj Frank Jensen, Per Nygaard
openalex +1 more source
Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase
Pharmaceutical and Biomedical Research, 2019 Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi +9 more
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Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations. [PDF]
Arch Iran Med, 2023 Alizadeh Z +6 more
europepmc +1 more source
Distributed Kernel K-Means for Large Scale Clustering
, 2017 Clustering samples according to an effective metric and/or vector space representation is a challenging unsupervised learning task with a wide spectrum of applications.
Decherchi, Sergio +2 more
core +1 more source
Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]
J Phys Chem B, 2023 Frost CF +3 more
europepmc +1 more source
Control of ATP homeostasis during the respiro‐fermentative transition in yeast
Molecular Systems Biology, 2010 Respiring Saccharomyces cerevisiae cells respond to a sudden increase in glucose concentration by a pronounced drop of their adenine nucleotide content ([ATP]+[ADP]+[AMP]=[AXP]).
Thomas Walther +6 more
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