Possible traces of resonance signaling in the genome [PDF]
arXiv, 2019 Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various ...
arxiv
Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase [PDF]
The use of E. coli purine nucleoside phosphorylase (PNP) to activate prodrugs has demonstrated excellent activity in the treatment of various human tumor xenografts in mice. E. coli PNP cleaves purine nucleoside analogs to generate toxic adenine analogs,
BW Hughes +26 more
core +2 more sources
BMC Cancer, 2011 Background Late stage Ovarian Cancer is essentially incurable primarily due to late diagnosis and its inherent heterogeneity. Single agent treatments are inadequate and generally lead to severe side effects at therapeutic doses.
Joshi Swapna +4 more
doaj +1 more source
Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]
J Phys Chem B, 2023 Frost CF +3 more
europepmc +1 more source
Solvable models of neighbor-dependent nucleotide substitution processes [PDF]
arXiv, 2005 We prove that a wide class of models of Markov neighbor-dependent substitution processes on the integer line is solvable. This class contains some models of nucleotide substitutions recently introduced and studied empirically by molecular biologists. We show that the polynucleotide frequencies at equilibrium solve explicit finite-size linear systems ...
arxiv
Control of ATP homeostasis during the respiro‐fermentative transition in yeast
Molecular Systems Biology, 2010 Respiring Saccharomyces cerevisiae cells respond to a sudden increase in glucose concentration by a pronounced drop of their adenine nucleotide content ([ATP]+[ADP]+[AMP]=[AXP]).
Thomas Walther +6 more
doaj +1 more source
Symmetry Analysis Of Genetic Code And Determinative Degree (in Russian) [PDF]
arXiv, 2000 A three-dimensional model of the genetic vocabulary is proposed in terms of determinative degree, an introduced characteristic of nucleotide, which reflects absolute difference between purin and pyrimidin bases in one DNA strand. In the fremework of this model manifest symmetry and group properties are described. It is proposed to use the determinative
arxiv
Nonlinear Dynamics in the Binary DNA/RNA Coding Problem [PDF]
arXiv, 2001 The presence of low dimensional chaos in the protein secondary structures, using the binary coded $\alpha$-helices and $\beta$-sheet motifs, has been investigated. In order to analyse symbolic DNA/RNA sequences the assignment, based on the purine/pyrimidine and strong/wea k H - bond classification sheme, of binary numbers to the nucleotides was made ...
arxiv
Purine nucleoside phosphorylase deficiency associated with a fatal lymphoproliferative disorder. [PDF]
, 1981 Alan R. Watson +4 more
openalex +1 more source
Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction. [PDF]
Nat Rev Urol, 2022 Birder LA, Jackson EK.
europepmc +1 more source