Results 181 to 190 of about 19,457 (231)

Adenine as Substrate for Purine Nucleoside Phosphorylase

Canadian Journal of Biochemistry, 1971
Purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) from four sources (rat liver and brain, human erythrocytes, and calf spleen) has been shown to exhibit a low intrinsic activity towards adenine in the presence of ribose 1-phosphate.
T P, Zimmerman, N B, Gersten, A F, Ross, R P, Miech   +3 more
openaire   +2 more sources

Characterization of purine nucleoside phosphorylase in leukemia

American Journal of Hematology, 1986
AbstractPurine nucleoside phosphorylase (PNP) activity was determined in mononuclear cells from 49 patients with various types of leukemia. A low level of PNP activity was found in mononuclear cells from patients with acute myeloid and lymphoblastic leukemia and with chronic lymphocytic leukemia. Enzymatic and immunological studies on PNP from leukemic
T, Morisaki, N, Horiuchi, H, Fujii, S, Miwa   +3 more
openaire   +2 more sources

Purine Nucleoside Phosphorylase. 1. Structure−Function Studies

Biochemistry, 1997
To probe the catalytic mechanism of human purine nucleoside phosphorylase (PNP), 13 active-site mutants were constructed and characterized by steady-state kinetics. In addition, microtiter plate assays were developed for both the phosphorolytic and synthetic reactions and used to determine the kinetic parameters of each mutant.
M D, Erion, K, Takabayashi, H B, Smith, J, Kessi, S, Wagner, S, Hönger, S L, Shames, S E, Ealick   +7 more
openaire   +2 more sources

[Purine nucleoside phosphorylase (PNP)].

Nihon rinsho. Japanese journal of clinical medicine, 1997
PNP, encoded by 6 exons on human chromosome 14q13, is a homotrimetic enzyme of approximately 96 k dalton. This enzyme reversibly catalyzes the phosphorolysis of purine nucleoside to their respective purine bases and the corresponding pentose-1-phosphate.
openaire   +1 more source

16 Purine Nucleoside Phosphorylase

1972
Publisher Summary This chapter focuses on purine nucleoside phosphorylases (PNPases), which are widely distributed in nature and have been identified and studied in a number of tissues in mammals, chickens, fish, yeast, and in several species of bacteria. In the erythrocytes of dogs, the activity of PNPase is remarkably low when compared with the red
openaire   +1 more source

Chapter 3. Purine Nucleoside Phosphorylase

2007
Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine ribonucleosides and 2′-deoxypurine ribonucleosides to the free base, and ribose 1-phosphate or 2′-deoxyribose 1-phosphate, respectively.1–3 PNPs are found in most prokaryotic and eukaryotic organisms where the en...
Yang Zhang, Steven E. Ealick
openaire   +1 more source

A Case with Purine Nucleoside Phosphorylase Deficiency Suffering from Late-Onset Systemic Lupus Erythematosus and Lymphoma

Journal of Clinical Immunology, 2020
B. Al-Saud, Zainab Al Alawi, Faisal Bin Hussain, M. Hershfield, F. Alkuraya, S. Al‐Mayouf   +5 more
semanticscholar   +1 more source

Purine nucleoside phosphorylase deficiency.

Immunodeficiency reviews, 1991
Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited disease accounting for approximately 4% of patients with severe combined immunodeficiency. Thirty-three patients have been reported. PNP-deficient patients suffer from recurrent infections, usually beginning in the first year of life. Two thirds of patients have evidence of neurologic
openaire   +1 more source

Thyroid purine nucleoside phosphorylase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
Jeffrey D. Carlson, Allan G. Fischer
openaire   +1 more source

Phosphorylase-catalyzed bottom-up synthesis of short-chain soluble cello-oligosaccharides and property-tunable cellulosic materials

Biotechnology Advances, 2021
Bernd Nidetzky, Chao Zhong
exaly