Results 41 to 50 of about 19,457 (231)
Partial Purine Nucleoside Phosphorylase Deficiency [PDF]
Journal of Clinical Investigation, 1978 Erwin W. Gelfand +3 more
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PNP (Purine Nucleoside Phosphorylase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 The purine nucleoside phosphorylase gene (PNP) encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. PNP is ubiquitously expressed in mammalian cells and tissues. PNP mutations cause nucleoside phosphorylase deficiency which result in defective T cell mediated immunity but can also affect B cell immunity and antibody ...
Gurbanov, Rafig, Tunçer, Sinem
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PNP inhibitors selectively kill cancer cells lacking SAMHD1
Molecular & Cellular Oncology, 2020 Purine nucleoside phosphorylase inhibitors (PNP-Is) were developed to ablate transformed lymphocytes. However, only some patients with leukemia benefit from PNP-Is. We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase
Tamara Davenne, Jan Rehwinkel
doaj +1 more source
An Enzymatic Flow-Based Preparative Route to Vidarabine
Molecules, 2020 The bi-enzymatic synthesis of the antiviral drug vidarabine (arabinosyladenine, ara-A), catalyzed by uridine phosphorylase from Clostridium perfringens (CpUP) and a purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP), was re-designed under ...
Lucia Tamborini +10 more
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Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu +7 more
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Purine Nucleoside Phosphorylase Deficiency [PDF]
Arthritis & Rheumatism, 1979 AbstractThe biochemical features of two families with purine nucleoside phosphorylase deficiency are compared. Laboratory studies and an evaluation of kinetic and physical properties of erythrocyte purine nucleoside phosphorylase give evidence that a) the degree of abnormality in uric acid and nucleoside concentrations in plasma and urine reflect the ...
Robert L. Wortmann +7 more
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Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
Molecules, 2005 Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. Theabsorption spectrum of some 5-substituted derivatives was found to extend to the visibleregion.
Jacek Wierzchowski +2 more
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Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice
Neurobiology of Disease, 2012 Inherited defects in purine nucleoside phosphorylase (PNP) cause severe T cell immunodeficiency and progressive neurological dysfunction, yet little is known about the effects of PNP deficiency on the brain.
Alireza Mansouri +9 more
doaj +1 more source
Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]
PLoS ONE, 2011 Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera +11 more
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Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites. [PDF]
PLoS ONE, 2014 Deoxyribosyl transferases and functionally related purine nucleoside phosphorylases are used extensively for synthesis of non-natural deoxynucleosides as pharmaceuticals or standards for characterizing and quantitating DNA adducts.
Wenjie Ye +10 more
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