Results 91 to 100 of about 76,319 (326)
Animal Research and One Health, EarlyView.The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang +6 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Fecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment associated with long‐term response to FMT.
Panpan Qin +7 more
wiley +1 more source
Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides
Molecules, 2015 Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj +1 more source
Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent
ChemMedChem, EarlyView.The binding affinity of triplex‐forming oligonucleotide (TFO) is successfully improved for human epidermal growth factor receptor type2 (HER2) gene sequence by using DNA intercalator. The higher binding affinity of TFO for HER2 gene sequence are correlated with the anticancer activity induced by the TFO and resulted in stronger cell death response of ...
Haruki Toyama +5 more
wiley +1 more source
Dampening of neurotransmitter action: molecular similarity within the melatonin structure
Endocrine Regulations, 2018 Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
doaj +1 more source
Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds
ChemMedChem, EarlyView.Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis +3 more
wiley +1 more source
Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies. [PDF]
Int J Mol Sci, 2021 Tomczyk M +4 more
europepmc +1 more source
ChemMedChem, EarlyView.Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych +11 more
wiley +1 more source
RNA Catabolites Contribute to the Nitrogen Pool and Support Growth Recovery of Wheat
Frontiers in Plant Science, 2018 Turn-over of RNA and catabolism of nucleotides releases one to four ammonia molecules; the released nutrients being reassimilated into primary metabolism.
Vanessa Jane Melino +8 more
doaj +1 more source