Results 111 to 120 of about 661,667 (342)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Phase separation of the PRPP amidotransferase into dynamic condensates promotes de novo purine synthesis in yeast.

PLoS Biology
De novo purine synthesis (DPS) is up-regulated under conditions of high purine demand to ensure the production of genetic materials and chemical energy, thereby supporting cell proliferation.
Masak Takaine, Rikuri Morita, Yuto Yoshinari, Takashi Nishimura   +3 more
doaj   +1 more source

RNA Catabolites Contribute to the Nitrogen Pool and Support Growth Recovery of Wheat

Frontiers in Plant Science, 2018
Turn-over of RNA and catabolism of nucleotides releases one to four ammonia molecules; the released nutrients being reassimilated into primary metabolism.
Vanessa Jane Melino, Vanessa Jane Melino, Alberto Casartelli, Jessey George, Thusitha Rupasinghe, Ute Roessner, Mamoru Okamoto, Sigrid Heuer, Sigrid Heuer   +8 more
doaj   +1 more source

Protective Effects of Auricularia auricula Polysaccharides on Acute Lung Injury by Regulating Intestinal Flora and Metabolism

Food Frontiers, EarlyView.
Auricularia auricula polysaccharides (AAP; 100, 200, and 400 mg/kg) protect against acute lung injury (ALI) by dose‐dependently remodeling the gut microbiota and modulating associated metabolic pathways via the gut‐lung axis, thereby enhancing pulmonary anti‐inflammatory and antioxidant capacity to ultimately prevent tissue damage.
Haili Niu, Fangjia Zhao, Qi Wang, Min Li, Yuan Li, Ivan Kurtovic, Zitong Zhang, Yahong Yuan, Tianli Yue   +8 more
wiley   +1 more source

An Interpretation of the Ancestral Codon from Miller's Amino Acids and Nucleotide Correlations in Modern Coding Sequences

Bioinformatics and Biology Insights, 2015
Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species.
Nicolas Carels, Miguel Ponce de Leon
doaj   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, EarlyView.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source

Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis

Journal of Lipid Research
A key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis.
Julia A. Pinette, Jacob W. Myers, Woo Yong Park, Heather G. Bryant, Alex M. Eddie, Genesis A. Wilson, Claudia Montufar, Zayedali Shaikh, Zer Vue, Elizabeth R. Nunn, Ryoichi Bessho, Matthew A. Cottam, Volker H. Haase, Antentor O. Hinton, Jessica B. Spinelli, Jean-Philippe Cartailler, Elma Zaganjor   +16 more
doaj   +1 more source

The Purine‐Nucleotide Cycle [PDF]

, 1980
Juan J. Aragón, John M. Lowenstein
openalex   +1 more source

Diagnosis and epidemiology of red blood cell enzyme disorders

Thalassemia Reports, 2013
The red blood cell possess an active metabolic machinery that provides the cell with energy to pump ions against electrochemical gradients, to maintain its shape, to keep hemoglobin iron in the reduced (ferrous) form, and to maintain enzyme and ...
Richard Van Wijk
doaj   +1 more source

Single molecule DNA sequencing via transverse electronic transport using a graphene nanopore: A tight-binding approach

, 2016
We report a tight-binding model study of two-terminal graphene nanopore based device, for sequential determination of DNA bases. Using Greens function approach we calculate conductance spectra, I-V response and also the changes in local density of states
Karmakar, S. N., Kundu, Sourav
core