Results 131 to 140 of about 76,319 (326)
Purine and pyrimidine nucleotide biosynthesis
Synthesis which is permiting purine and pyrimidine analogs with potential as anticancer drugs to be incorporated into DNA. The most important regulator of de novo purine biosynthesis is the intracellular concentration of phosphoribosyl-pyrophosphate. The synthesis rates of purine and pyrimidine oxyribonucleotides and deoxyribonucleotides for parameters
J. Savkovic Stevanovic, R. Stevanović
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Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies
VIEW, EarlyView.Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan +6 more
wiley +1 more source
Effects of limiting different purine nucleotide precursors on nucleic acid synthesis and nucleotide pools of purine-requiring mutants of Escherichia coli [PDF]
, 1969 Greg A. Jeffries, K. Burton
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ENZYMATIC SYNTHESIS OF PURINE NUCLEOTIDES
Journal of Biological Chemistry, 1955 Ernest S. Simms +2 more
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Molecular Ecology Resources, EarlyView.ABSTRACT Assessing and monitoring genetic diversity is vital for understanding the ecology and evolution of natural populations but is often challenging in animal and plant species due to technically and physically demanding tissue sampling. Although environmental DNA (eDNA) metabarcoding is a promising alternative to the traditional population genetic
Yusuke Koseki +5 more
wiley +1 more source
Aging Cell, EarlyView.A metabolite‐based score for short‐term unintentional weight loss was independently associated with mortality and mobility limitation risks in healthy older adults. It accounted for over 20% of the excess risk linked to unintentional weight loss, independent of lifestyle and medical history, suggesting a shared metabolic mechanism that remains ...
Shanshan Yao +7 more
wiley +1 more source
IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth
Cell ReportsSummary: Inosine monophosphate dehydrogenase 2 (IMPDH2) is highly expressed in human cancers; however, its physiological relevance under growth signaling remains to be investigated. Here, we show that IMPDH2 serine 122 is phosphorylated by CDK1, and this
Bei Zhou +10 more
doaj +1 more source
The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression
Aging Cell, EarlyView.A multi‐omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machinery of the heart; a likely compensatory increase in energetic flux and redox reductive capacity; and an increase in lysosomal activity.
Cassandra Malecki +20 more
wiley +1 more source
Breast and Nipple Dermatoses During Lactation
Australasian Journal of Dermatology, EarlyView.ABSTRACT Lactation and breastfeeding can present both psychological and physical challenges for breastfeeding mothers. In addition, many nursing mothers will also suffer from breast and nipple dermatoses during this period, compounding these difficulties. Common causes of breast and nipple dermatitis during lactation include eczema, psoriasis, mastitis,
Hamish Moore, Annabel Stevenson
wiley +1 more source
Purine Nucleosides and Nucleotides Unequivocally in the Syn Conformation: Guanosine and 5′-GM P with 8-tert-Butyl and 8-( α-Hydroxyisopropyl) Substituents [PDF]
, 1978 Reynaldo C. Pless +3 more
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