Results 261 to 270 of about 76,319 (326)

Dietary supplementation with glutamate improves the flesh quality of gibel carp (<i>Carassius gibelio</i>) by altering muscle texture characteristics and increasing the deposition of flavour substances. [PDF]

J Nutr Sci
Cai W, Wang X, Liu H, Hua L, Han D, Zhu X, Jin J, Zhang Z, Yang Y, Xie S.   +9 more
europepmc   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, Volume 292, Issue 18, Page 4753-4773, September 2025.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

Methylation of Cytidine 1407 Increases the Lifetimes of the A-Site Ground and Excited States of <i>E. coli</i> 16S Ribosomal RNA. [PDF]

J Am Chem Soc
Hilber S, Marotto A, Mitteregger C, Tollinger M, Kreutz C.   +4 more
europepmc   +1 more source

Emerging roles for integrated stress response signaling in homeostasis

The FEBS Journal, Volume 292, Issue 17, Page 4418-4445, September 2025.
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress‐adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of literature and presents several homeostatic functions of ISR in the absence of stress: (a) developmental processes (morphogenesis, differentiation, aging), (
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan   +2 more
wiley   +1 more source

Purine nucleobases enhance CD8⁺ T cell effector function

Genger J, Haladik B, Lercher A, Agerer B, Mangana C, Amman F, Viczenczova C, Hohl T, Hofmann A, Koblischke M, Kratzer B, Li W, Zinober K, Kartnig F, Schüller C, Koren A, Lin JG, Maier BB, Bock C, Kralovics R, Argüello RJ, Aberle JH, Reiberger T, Pickl WF, Superti-Furga G, Klavins K, Hannich JT, Kubicek S, Bergthaler A.   +28 more
europepmc   +1 more source

Cleavage sequence specificity of Nsp15. [PDF]

RNA Biol
McGuire JV, Horowitz S.
europepmc   +1 more source

Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage. [PDF]

Signal Transduct Target Ther
Yue Y, Li Q, Chen C, Yang J, Song W, Zhou C, Cui Y, Wei Z, He Q, Wang C, Lin H, Li J, Li J, Xi J, Song X, Yang W, Zhang Z, Shu W, Guo L, Wang S.   +19 more
europepmc   +1 more source

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase

Molecular Microbiology, Volume 124, Issue 3, Page 189-203, September 2025.
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Claire E. Stevens, Ashley T. Deventer, Paul R. Johnston, Phillip T. Lowe, Alisdair B. Boraston, Joanne K. Hobbs   +5 more
wiley   +1 more source

Nonenzymatic RNA copying with a potentially primordial genetic alphabet. [PDF]

Proc Natl Acad Sci U S A
Fang Z, Jia X, Xing Y, Szostak JW.
europepmc   +1 more source

Ustilago maydis Nit2 Regulates Nitrate Utilisation During Biotrophy and Affects Amino Acid Metabolism of Galls Under Nitrogen Depletion

Molecular Plant Pathology, Volume 26, Issue 9, September 2025.
The transcription factor Nit2 of the smut Ustilago maydis controls nitrate utilisation during biotrophy and affects steady state nitrate and amino acid contents in maize leaf galls under nitrogen depletion. ABSTRACT In previous work, we have shown that the transcription factor Nit2 plays a major role in the utilisation of non‐favoured nitrogen sources ...
Philipp L. Lopinski, Christin Schulz, Alicia Fischer, Nadine Reichl, Timo Engelsdorf, Nadja Braun, Lars M. Voll   +6 more
wiley   +1 more source