Results 71 to 80 of about 76,319 (326)

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]

, 2010
Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Noeske, Jonas, Schwalbe, Harald (Prof. Dr.), Wöhnert, Jens   +2 more
core  

Symmetry Scheme for Amino Acid Codons

, 2003
Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid ...
F. Zinoni, G. E. Garcia, I. Chambers, J. Balakrishnan, J. E. M. Hornos, J. E. M. Hornos, J. E. M. Hornos, J. F. Atkins, J. L. Cornette, M. Forger, M. J. Berry, R. Slansky   +11 more
core   +1 more source

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
A. Teml, A.A. van Bodegraven, Al Hadithy AF, Artlich A, Bean RHD, Buffet C, C.J.J. Mulder, Carter MJ, Daniel F, De Boer N, de Boer NK, de Boer NK, de Jong D, Derijks LJ, Dervieux T, Dubinsky MC, Ferlitsch A, Fonseca V, Gane E, Gearry RB, H. Vogelsang, Haboubi NY, Herrlinger KR, Herrlinger KR, Herrlinger KR, J. Seiderer, Jones MC, K.R. Herrlinger, Katzka DA, Lilleyman JS, M. Lukas, M. Schwab, Marinaki AM, McBride KL, N.K.H. de Boer, Naber AH, P. Knoflach, Russmann S, Rutgeerts P, S. Almer, S.W. van der Merwe, Sandborn W, Schaeffeler E, Seiderer J, Shastri S, T. Ochsenkühn, Teml A, Teml A, Teml A, Tiede I, van Dieren JM, W. Petritsch, W. Reinisch   +52 more
core   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma [PDF]

, 2018
Brain tumor initiating cells (BTICs), also known as cancer stem cells, hijack high-affinity glucose uptake active normally in neurons to maintain energy demands.
Bao, Shideng, Fang, Xiaoguang, Flavahan, William A, Huang, Zhi, Hubert, Christopher G, Hwang, Tae Hyun, Kim, Leo J Y, Liu, Xiaojing, Locasale, Jason W, Mack, Stephen C, Miller, Tyler E, Prager, Briana C, Regev, Aviv, Rich, Jeremy N, Shi, Yu, Singer, Meromit, Suvà, Mario L, Wang, Xiuxing, Wu, Qiulian, Xie, Qi, Yang, Kailin, Zhou, Wenchao   +21 more
core   +1 more source

Anti‐Icing Organogel Enables Quasi‐Homogeneous Supercooling Preservation of Mouse Hearts

Advanced Science, EarlyView.
An organogel interface with a large energy barrier for ice nucleation is proposed to enable a quasi‐homogeneous supercooling preservation for organs. This method does not rely on cryoprotectant agents or machine perfusion and can double the ex vivo storage time of mouse hearts.
Junhao Li, Wei Wang, Chenghao Li, Lintao Kuang, Zhi Huang, Xing Chen, Zhenghao Guo, Kang Liu, Jinping Liu   +8 more
wiley   +1 more source

Effects of cyclic adenosine 3,5-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation. [PDF]

, 1982
As a test of the hypothesis that cyclic nucleotides play a role in the regulation of retinomotor movements and disc shedding in the photoreceptor-pigment epithelial complex, we have used an in vitro eyecup preparation that sustains both disc shedding and
Besharse, J, BURNSIDE, Beth, Dunis, D
core   +1 more source

A minimum principle in mRNA editing ?

, 2001
mRNA editing of sequences of many species is analyzed. The nature of the inserted nucleotides and the position of the insertion sites, once fixed the edited peptide chain, are explained by introducing a minimum principle in the framework of the crystal ...
Frappat, L., Sciarrino, A., Sorba, P.
core   +2 more sources

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum, Blackburn, Gavin, Daskalaki, Evangelia, Kalna, Gabriela, Watson, David, Zhang, Tong   +5 more
core   +2 more sources

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

Advanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang, Xianli Zhang, Yuanyuan Zhou, Shuyi Lin, Yuting Fu, Haiping Liu, Qiongdan Gao, YanHong Xiao, Zhao Yin, Shuang Liu, Kexiu Huang, Suqi Deng, Juan Du, Hui Zeng, Jia Wang, Jinping Zheng, Qinghua Zhou, Tianfeng Chen, Xiaoling Gao, Zhenyu Ju, Bo Liu   +20 more
wiley   +1 more source