Results 61 to 70 of about 1,369,940 (235)
Environmental Toxicology and Chemistry, EarlyView.Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers +10 more
wiley +1 more source
Purinergic signaling in the cerebellum
, 2023 Purinergic signaling is a complex and evolutionarily conserved mechanism of extracellular communication involved in many physiological and pathological functions.
Wall, Mark J., Mark J. Wall
core +1 more source
Purinergic Receptors in Thrombosis and Inflammation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 Under various pathological conditions, including thrombosis and inflammation, extracellular nucleotide levels may increase because of both active release and passive leakage from damaged or dying cells. Once in the extracellular compartment, nucleotides interact with plasma membrane receptors belonging to the P2 purinergic family, which ...
Hechler, Beatrice, Gachet, Christian
openaire +2 more sources
iMetaMed, EarlyView.This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang +13 more
wiley +1 more source
Cell Journal, 2017 Objective: Due to recent progress in production of human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-OPCs) for ameliorating myelin disease such as multiple sclerosis (MS) and the role of purinergic signaling in OPCs development,
Shirin Kashfi +5 more
doaj +1 more source
The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario +3 more
wiley +1 more source
Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity
Frontiers in Pharmacology, 2018 Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis.
Milka Koupenova, Katya Ravid
doaj +1 more source
Neurourology and Urodynamics, EarlyView.ABSTRACT Objective To explore molecular mechanisms underlying excessive extracellular adenosine (ADO) accumulation in the bladder lamina propria (LP) of mice with type 2 diabetes (T2D) induced by a high‐fat, high‐sucrose diet (HFHSD), conceivably leading to bladder underactivity.
Mahsa Borhani Peikani +2 more
wiley +1 more source
Activation of purinergic receptor subtypes modulates odor sensitivity
, 2003 Purinergic nucleotides, including ATP and adenosine, are important neuromodulators of peripheral auditory and visual sensory systems (Thorne and Housley, 1996).
Lucero, MT +4 more
core +2 more sources
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source