Results 41 to 50 of about 39,382 (265)

Purinergic signaling in schistosomal infection

Biomedical Journal, 2016
Human schistosomiasis is a chronic inflammatory disease caused by blood fluke worms belonging to the genus Schistosoma. Health metrics indicate that the disease is related to an elevated number of years lost-to-disability and years lost-to-life ...
Claudia Lucia Martins Silva
doaj   +1 more source

Purinergic signaling in the gastrointestinal tract

, 2011
Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Geoffrey Burnstock, Burnstock, G
core   +1 more source

Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway [PDF]

, 2008
The Breuer-Hering inflation reflex is initiated by activation of the slowly adapting pulmonary stretch receptor afferents (SARs), which monosynaptically activate second-order relay neurones in the dorsal medullary nucleus of the solitary tract (NTS ...
Enrique Llaudet, Gourine, Alexander V., Robert Huckstepp, Faming Tian, K. Michael Spyer, Korsak, Alla, Dale, Nicholas, Huckstepp, Robert T. R., Tian, Faming, Alexander V. Gourine, Spyer, K. Michael, Llaudet, Enrique, Alla Korsak, Nicholas Dale   +13 more
core   +1 more source

Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder

, 2007
Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, G., Tasker, Paul N., Kennedy, C., Kennedy, Charles, Westfall, T., Westfall, Timothy D., Tasker, P., Gallagher, Gemma   +7 more
core   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Lalo, Ulyana, Pankratov, Yuriy, Verkhratsky, A. N. (Alekseĭ Nestorovich), Wichert, S., Kirchhoff, F., Rossner, Moritz J., Verkhratsky, Alexei; id_orcid, Kirchhoff, Frank, Verkhratsky, Alexei, Pankratov, Y., Rossner, M., Lalo, U., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), North, R., Pankratov, Yuri, North, R. Alan, Verkhratsky, A., Wichert, Sven P.   +17 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]

, 2002
The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas, Nicholas Dale
core   +1 more source

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel, Ricardo Espinosa-Tanguma, Madeline Nieves-Cintron, Manuel F. Navedo   +3 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source