Results 31 to 40 of about 1,272,508 (252)

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology.
Kazuaki Yoshioka, Hiroyasu Nakata
doaj   +1 more source

Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?

Frontiers in Allergy, 2021
Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airways. Consequently,
Rebecca J. Thompson, Ian Sayers, Katja Kuokkanen, Ian P. Hall   +3 more
doaj   +1 more source

Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors

Molecules, 2023
ATP acts in the extracellular environment as an important signal, activating a family of receptors called purinergic receptors. In recent years, interest in the potential therapeutics of purinergic components, including agonists and antagonists of ...
Paulo Anastácio Furtado Pacheco, Daniel Tadeu Gomes Gonzaga, Natalia Lidmar von Ranke, Carlos Rangel Rodrigues, David Rodrigues da Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Robson Xavier Faria   +7 more
doaj   +1 more source

Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy

Frontiers in Pharmacology, 2018
Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system.
Ágatha Oliveira-Giacomelli, Yahaira Naaldijk, Laura Sardá-Arroyo, Maria C. B. Gonçalves, Juliana Corrêa-Velloso, Micheli M. Pillat, Héllio D. N. de Souza, Henning Ulrich   +7 more
doaj   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ, Eilidh eCraigie, Scott S Wildman, Wildman, Scott S.P., Eilidh Craigie, Rebecca E. Birch, Robert John Unwin, Craigie, Eilidh, Craigie, E, Rebecca E Birch, Unwin, Robert J., Unwin, Robert J, Birch, Rebecca E., Birch, RE, Robert J. Unwin, Wildman, SS, Scott S. Wildman, Birch, Rebecca E, Wildman, Scott   +18 more
core   +1 more source

Purines, Purinergic Receptors, and Cancer [PDF]

Cancer Research, 2012
AbstractPurines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent ...
openaire   +3 more sources

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad   +17 more
core   +2 more sources

Purine and purinergic receptors in health and disease

MedComm, 2023
Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai, Hengyi Wang, Lu Liu, Yulin Qi, Shiyun Tang, Jianyuan Tang, Nianzhi Chen   +6 more
doaj   +1 more source

Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain

Folia Neuropathologica, 2022
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec, Anna Wilkaniec, Agata Adamczyk   +2 more
doaj   +1 more source