Results 31 to 40 of about 1,369,940 (235)

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]

J Innate Immun
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Forde L, Gogoi D, Baird R, McCarthy C, Keane MP, Reeves EP, McGrath EE.   +6 more
europepmc   +4 more sources

Purines as potential morphogens during embryonic development [PDF]

, 2012
Components of purinergic signalling are expressed in the early embryo raising the possibility that ATP, ADP and adenosine may contribute to the mechanisms of embryonic development.
Dale, Nicholas, Masse, Karine, Karine Massé, Nicholas Dale   +3 more
core   +1 more source

Purines, Purinergic Receptors, and Cancer [PDF]

Cancer Research, 2012
AbstractPurines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent ...
openaire   +3 more sources

Purine and purinergic receptors in health and disease

MedComm, 2023
Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai, Hengyi Wang, Lu Liu, Yulin Qi, Shiyun Tang, Jianyuan Tang, Nianzhi Chen   +6 more
doaj   +1 more source

Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone [PDF]

, 2002
Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials.
Catsicas, M., Peter Mobbs, Pearson, R., Pearson, Rachel; id_orcid, Becker, D., Pearson, R, Rachel Pearson, Becker, D, Mobbs, P, Becker, David, Marina Catsicas, Catsicas, Marina, Catsicas, M, Mobbs, Peter, David Becker, Mobbs, P.   +15 more
core   +1 more source

Purinergic receptors in cognitive disturbances

Neurobiology of Disease, 2023
Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-sensitive classes broadly interfere with cognitive processes both under quasi normal and disease conditions. During neurodegenerative illnesses, high concentrations of ATP are released from the damaged neuronal and non-neuronal cells of the brain; then, this ATP is ...
Peter Illes, Henning Ulrich, Jiang-Fan Chen, Yong Tang   +3 more
openaire   +3 more sources

Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia

Journal of Neuroinflammation, 2009
Microglia are implicated in multiple neurodegenerative disorders, many of which display sexual dimorphisms and have symptom onsets at different ages. P2 purinergic receptors are critical for regulating various microglial functions, but little is known ...
Nikodemova Maria, Crain Jessica M, Watters Jyoti J   +2 more
doaj   +1 more source

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad, Pankratov Yuriy, Lalo Ulyana, Andrew Jemma, Palygin Oleg, Rasooli-Nejad Seyed, Haydon Philip G.   +23 more
core   +2 more sources

Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain

Folia Neuropathologica, 2022
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec, Anna Wilkaniec, Agata Adamczyk   +2 more
doaj   +1 more source