Results 11 to 20 of about 39,494 (229)
Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma [PDF]
Frontiers in Pharmacology, 2017 Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Begoña Fonseca +5 more
doaj +3 more sources
Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy [PDF]
Frontiers in NeuroscienceEpilepsy is one of the most prevalent neurological disorders globally. Current treatments mainly target neuronal activity, often overlooking the involvement of astrocytes and microglia in epilepsy’s pathophysiology.
Nelson Espinosa +9 more
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Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]
J Innate ImmunBackground: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Forde L +6 more
europepmc +4 more sources
Purinergic Signalling: Therapeutic Developments [PDF]
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
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Bradykinin increases resensitization of purinergic receptor signaling in glioma cells [PDF]
Cancer Cell International, 2010 Background Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain tumors and may correlate with ...
Brennan Kevin C +3 more
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Purinergic Receptors in Ocular Inflammation [PDF]
Mediators of Inflammation, 2014 Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ.
Ana Guzman-Aranguez +3 more
openaire +5 more sources
Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion
Viruses, 2020 Purinergic receptors are inflammatory mediators activated by extracellular nucleotides released by dying or injured cells. Several studies have described an important role for these receptors in HIV-1 entry, particularly regarding their activity on HIV-1
Tracey L. Freeman, Talia H. Swartz
doaj +1 more source
Purinergic signaling in infection and autoimmune disease
Biomedical Journal, 2016 Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites.
Luiz Eduardo Baggio Savio +1 more
doaj +1 more source
Brain Research Bulletin, 2023 Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
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Purine and purinergic receptors [PDF]
Brain and Neuroscience Advances, 2018 Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ...
openaire +2 more sources