Results 11 to 20 of about 39,382 (265)
Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma
Frontiers in Pharmacology, 2017 Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Begoña Fonseca +5 more
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Purinergic Signalling: Therapeutic Developments [PDF]
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
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Bradykinin increases resensitization of purinergic receptor signaling in glioma cells [PDF]
Cancer Cell International, 2010 Background Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain tumors and may correlate with ...
Brennan Kevin C +3 more
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Brain Sciences, 2023 Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec +5 more
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Purinergic Receptors in Ocular Inflammation [PDF]
Mediators of Inflammation, 2014 Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ.
Ana Guzman-Aranguez +3 more
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Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion
Viruses, 2020 Purinergic receptors are inflammatory mediators activated by extracellular nucleotides released by dying or injured cells. Several studies have described an important role for these receptors in HIV-1 entry, particularly regarding their activity on HIV-1
Tracey L. Freeman, Talia H. Swartz
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Brain Research Bulletin, 2023 Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
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Purinergic signaling in infection and autoimmune disease
Biomedical Journal, 2016 Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites.
Luiz Eduardo Baggio Savio +1 more
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Purine and purinergic receptors [PDF]
Brain and Neuroscience Advances, 2018 Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ...
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Journal of Pharmacological Sciences, 2004 Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology.
Kazuaki Yoshioka, Hiroyasu Nakata
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