Results 71 to 80 of about 1,272,650 (214)

Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses

Journal of Pharmacological Sciences, 2022
Adenosine triphosphate (ATP) initially attracted attention as a neurotransmitter, with much research conducted on the regulation of neurotransmission in the autonomic and central nervous systems.
Isao Matsuoka, Kazuki Yoshida, Masa-aki Ito   +2 more
doaj   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Elevated Pressure Changes the Purinergic System of Microglial Cells

Frontiers in Pharmacology, 2018
Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy.
Ana C. Rodrigues-Neves, Ana C. Rodrigues-Neves, Inês D. Aires, Inês D. Aires, Joana Vindeirinho, Joana Vindeirinho, Raquel Boia, Raquel Boia, Maria H. Madeira, Maria H. Madeira, Francisco Q. Gonçalves, Francisco Q. Gonçalves, Rodrigo A. Cunha, Rodrigo A. Cunha, Rodrigo A. Cunha, Paulo F. Santos, Paulo F. Santos, Paulo F. Santos, António F. Ambrósio, António F. Ambrósio, António F. Ambrósio, António F. Ambrósio, Ana R. Santiago, Ana R. Santiago, Ana R. Santiago, Ana R. Santiago   +25 more
doaj   +1 more source

Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. [PDF]

PLoS ONE, 2016
A rapid test to identify drugs that affect autonomic responses to hypoxia holds therapeutic and ecologic value. The zebrafish (Danio rerio) is a convenient animal model for investigating peripheral O2 chemoreceptors and respiratory reflexes in ...
Saman Rahbar, Wen Pan, Michael G Jonz
doaj   +1 more source

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Purinergic System Signaling in Metainflammation-Associated Osteoarthritis

Frontiers in Medicine, 2020
Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade inflammation caused by the components involved in metabolic syndrome (MetS), including central obesity and impaired glucose tolerance. This phenomenon is mainly due
Paula Gratal, Ana Lamuedra, Juan Pablo Medina, Ismael Bermejo-Álvarez, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero   +6 more
doaj   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Purinergic Signaling in Swallowing Reflex Initiation: Mechanisms and Therapeutic Implications for Oropharyngeal Dysphagia—A Narrative Review

Cells
The swallowing reflex is a highly coordinated process that is essential for safe bolus transit and airway protection. Although its neurophysiological framework has been extensively studied, the molecular mechanisms underlying reflex initiation remain ...
Junrong Qi, Mohammad Zakir Hossain, Hiroshi Ando, Rita Rani Roy, Junichi Kitagawa   +4 more
doaj   +1 more source

The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway

Neurobiology of Pain, 2020
Naked mole-rats (Heterocephalus glaber) have adaptations within their pain pathway that are beneficial to survival in large colonies within poorly ventilated burrow systems, with lower O2 and higher CO2 ambient levels than ground-level environments ...
Brigitte M. Browe, Abigail R. Olsen, Cesar Ramirez, Rebecca H. Rickman, Ewan St. John Smith, Thomas J. Park   +5 more
doaj   +1 more source