Results 91 to 100 of about 1,369,940 (235)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

The P2X receptor mediated regulation of inhibitory synaptic transmission [PDF]

In the central nervous system ATP can be released by neurons and glial cells through similar pathways as other neurotransmitters. Extracellular ATP targets P2X purinoreceptors, causing an influx of Ca2+ ions which transmit very important messages for ...
Andrew-Adiamah, Jemma
core  

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile

, 2021
Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype.
Zur Mühlen, Constantin von, Hertle, L., Zirlik, A., Garlen, Sunaina von, Bode, C., Hilgendorf, I., Hilgendorf, Inken, Wolf, D., Nettesheim, A., Saller, Benedikt S., Schäfer, Ibrahim, Bulatova, Kseniya, von Garlen, S., Merz, Julian, Bode, Christoph, König, S., Bulatova, K., Karnbrock, Lorenz, von zur Mühlen, C., Wolf, Dennis, Hoppe, Natalie, Peikert, A., Karnbrock, L., Engelmann, J., Dimanski, D., Albrecht, P., Saller, B. S., Hoppe, N., Engelmann, Juliane, Groß, O., Zirlik, Andreas, Groß, Olaf, Schäfer, I., Dimanski, Daniel, Albrecht, Philipp, Stachon, Peter, Merz, J., Peikert, Alexander, B. S. Saller, J. Merz, C. von zur Mühlen, K. Bulatova, I. Schäfer, D. Dimanski, N. Hoppe, L. Karnbrock, A. Peikert, O. Groß, I. Hilgendorf, A. Zirlik, P. Albrecht, A. Nettesheim, C. Bode, P. Stachon, S. von Garlen, J. Engelmann, L. Hertle, S. König, D. Wolf   +58 more
core   +1 more source

Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

Biomedical Journal, 2016
Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell ...
Francesco Di Virgilio, Anna Lisa Giuliani   +1 more
doaj   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Purinergic signaling during Porphyromonas gingivalis infection

Biomedical Journal, 2016
Despite recent advances unraveling mechanisms of host–pathogen interactions in innate immunity, the participation of purinergic signaling in infection-driven inflammation remains an emerging research field with many unanswered questions.
Cássio Luiz Coutinho Almeida-da-Silva, Ana Carolina Morandini, Henning Ulrich, David M. Ojcius, Robson Coutinho-Silva   +4 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Variation in the purinergic P2RX(7) receptor gene and schizophrenia

, 2008
The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is
Fenger, Mogens, Krane, Karoline, Hansen, Thomas, Lublin, Henrik, Timm, Sally, Ullum, Henrik, Jakobsen, Klaus D, Jørgensen, Niklas Rye, Wang, August G, Werge, Thomas, Fink-Jensen, Anders, Nielsen, Jimmi   +11 more
core   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source