Results 101 to 110 of about 1,369,940 (235)

Nutrient‐specific combinatorial secretion of GLP‐1 and neurotransmitters in the enteroendocrine L‐cell line GLUTag

The FEBS Journal, EarlyView.
Enteroendocrine L cells function as chemosensors in the intestine. Using the L‐cell line GLUTag, we show that distinct nutrients trigger different combinations of co‐secretion of GLP‐1 and neurotransmitters: D‐glucose evokes GLP‐1, glutamate, and ATP; L‐glutamine evokes GLP‐1 and glutamate; sucralose and butyrate evoke only GLP‐1.
Yo Ito, Kazuki Harada, Yuri Osuga‐Yoshiike, Masami Yokota Hirai, Tetsuya Kitaguchi, Takashi Tsuboi   +5 more
wiley   +1 more source

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation

Cell Reports, 2017
Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear.
Youichi Shinozaki, Keisuke Shibata, Keitaro Yoshida, Eiji Shigetomi, Christian Gachet, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi   +7 more
doaj   +1 more source

Synergistic Effects of Bacterial Mimetic and Mechanical Stimulation in Dental Pulp Cell Inflammatory Signalling: A Laboratory Investigation

International Endodontic Journal, EarlyView.
ABSTRACT Objectives Mechanical and/or microbial stimuli can prompt extracellular ATP release in many cell types, where it acts as an inflammatory mediator to amplify pain signals and inflammation. This study aimed to investigate the synergistic effects of microbial and/or mechanical stimulation on ATP and cytokine release from dental pulp cells (DPCs ...
Orla M. Dunne, Lorcan P. McGarvey, Imad About, Fionnuala T. Lundy, Ikhlas El‐Karim   +4 more
wiley   +1 more source

P2X7 receptor contributes to hepatic inflammation and collagen deposition in methionine- and choline-deficient diet-fed mice

Frontiers in Pharmacology
IntroductionMetabolic-Dysfunction-Associated Steatohepatitis (MASH) is characterized by hepatic steatosis, inflammation, and progressive liver injury, with growing evidence implicating purinergic signaling and inflammasome activation in disease ...
Sthefani Rodrigues Batista da Silva, Fabiana Cristina-Rodrigues, Mariana M. Chaves, Mariana M. Chaves, Isabele Pinheiro Cruz, Isabele Pinheiro Cruz, Lorraine de Oliveira da Cruz, Maria Fernanda Carvalho de Araujo, Soraia das Neves Vieira Cavalcanti, Georgia Correa Atella, Christina Maeda Takiya, Luiz Eduardo Baggio Savio, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva   +13 more
doaj   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Role of purinergic receptors in the activation of human airway smooth muscle cells by the antimicrobial peptide LL-37

European Respiratory Review, 2006
Inflammatory cells that infiltrate and surround the airway smooth muscle (ASM) layer express antimicrobial peptides including the cathelicidin LL-37.
Suzanne Zuyderduyn, Dennis. K. Ninaber, Pieter. S. Hiemstra, Klaus. F. Rabe   +3 more
doaj  

Purinergic stimulation of K+-dependent Na+/Ca2+ exchanger isoform 4 requires dual activation by PKC and CaMKII

Bioscience Reports, 2013
K+-dependent Na+/Ca2+-exchanger isoform 4 (NCXK4) is one of the most broadly expressed members of the NCKX (K+-dependent Na+/Ca2+-exchanger) family.
Xu Yang, Jonathan Lytton
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]

, 2014
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H., Fountain, Samuel J., Sexton, D. W., Campwala, Hinnah, Fountain, SJ, Crossman, David C., Sexton, Darren W., Campwala, H, Crossman, D. C., Fountain, S. J., Sexton, DW, Crossman, DC, Crossman, David C.; id_orcid   +12 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source