Results 121 to 130 of about 1,369,940 (235)
eLifeMicroglia regulate anesthesia by altering the activity of neurons in specific regions of the brain via a purinergic receptor.
Romeesa Khan, Rodney M Ritzel
doaj +1 more source
KV channels contribute to thermal hyperaemia in skeletal muscle of humans
The Journal of Physiology, EarlyView.Abstract figure legend Using skeletal muscle microdialysis and pulsed short‐wave diathermy, we examined the contribution of KV channels to thermal hyperaemia in human skeletal muscle. KV channel antagonism with 4‐aminopyridine attenuated thermal hyperaemia by ∼65%, identifying a critical downstream role for these ion channels in the vasodilatory ...
Ysabella I. Ruiz‐Pick +5 more
wiley +1 more source
Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity
Glia, Volume 74, Issue 12, December 2026.The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert +2 more
wiley +1 more source
Neuropathology and Applied Neurobiology, Volume 52, Issue 6, December 2026.A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Wei Jiang +4 more
wiley +1 more source
Pharmacological ResearchMajor depressive disorder (MDD) is a mental illness characterized primarily by persistent low mood and anhedonia. Traditional monoamine antidepressants have not achieved entirely satisfactory clinical efficacy.
Xing-Ying Ren +4 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha +9 more
wiley +1 more source
Glia, Volume 74, Issue 11, November 2026.Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton +6 more
wiley +1 more source
ADP receptor P2Y(13) induce apoptosis in pancreatic beta-cells.
, 2010 Pancreatic beta-cell loss represents a key factor in the pathogenesis of diabetes. Since the influence of purinergic signaling in beta-cell apoptosis has not been much investigated, we examined the role of the ADP receptor P2Y(13) using the pancreatic ...
Erlinge, David, +9 more
core +1 more source
Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough
The Laryngoscope, Volume 136, Issue 11, Page 4938-4944, November 2026.The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen +3 more
wiley +1 more source