Results 11 to 20 of about 53,110 (258)

Purinergic receptors in cognitive disturbances

Neurobiology of Disease, 2023
Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-sensitive classes broadly interfere with cognitive processes both under quasi normal and disease conditions.
Peter Illes, Henning Ulrich, Jiang-Fan Chen, Yong Tang   +3 more
doaj   +3 more sources

Purinergic Receptors in Ocular Inflammation [PDF]

Mediators of Inflammation, 2014
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease.
Ana Guzman-Aranguez, Xavier Gasull, Yolanda Diebold, Jesús Pintor   +3 more
doaj   +5 more sources

Global trends of purinergic receptors and depression: A bibliometric analysis from 2003 to 2023. [PDF]

World J Psychiatry
Huang B, Chen WN, Peng CM, Shen XL, Xue J, Yan CC, Zhong FM.   +6 more
europepmc   +2 more sources

Purinergic Receptors Crosstalk with CCR5 to Amplify Ca²⁺ Signaling. [PDF]

Cell Mol Neurobiol, 2021
Horioka M, Ceraudo E, Lorenzen E, Sakmar TP, Huber T.   +4 more
europepmc   +3 more sources

Purinergic signaling in the male reproductive tract

Frontiers in Endocrinology, 2022
Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin, Kéliane Brochu, Christine Légaré, Maria Agustina Battistone, Sylvie Breton   +4 more
doaj   +1 more source

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +16 more sources

Purinergic Signaling in Liver Pathophysiology

Frontiers in Endocrinology, 2021
Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
doaj   +1 more source

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

Painful Purinergic Receptors [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2008
Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive sensitivity following tissue injury. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and ...
Diana, Donnelly-Roberts, Steve, McGaraughty, Char-Chang, Shieh, Prisca, Honore, Michael F, Jarvis   +4 more
openaire   +2 more sources

Purine and purinergic receptors [PDF]

Brain and Neuroscience Advances, 2018
Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ectonucleotidases.
Geoffrey Burnstock
openalex   +3 more sources