Results 21 to 30 of about 32,402 (193)

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Journal of Pharmaceutical Analysis, 2023
Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen, Tian Li, Dehua Huang, Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou   +8 more
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology.
Kazuaki Yoshioka, Hiroyasu Nakata
doaj   +1 more source

Purinergic signaling: A gatekeeper of blood-brain barrier permeation

Frontiers in Pharmacology, 2023
This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Yuemei Wang, Yuanbing Zhu, Junmeng Wang, Longcong Dong, Shuqing Liu, Sihui Li, Qiaofeng Wu   +6 more
doaj   +1 more source

Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma

Frontiers in Pharmacology, 2017
Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Begoña Fonseca, Alejandro Martínez-Águila, María J. Pérez de Lara, Maria Teresa Miras-Portugal, Rosa Gómez-Villafuertes, Jesús Pintor   +5 more
doaj   +1 more source

Purines, Purinergic Receptors, and Cancer [PDF]

Cancer Research, 2012
AbstractPurines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent ...
openaire   +3 more sources

Purinergic receptors in cognitive disturbances

Neurobiology of Disease, 2023
Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-sensitive classes broadly interfere with cognitive processes both under quasi normal and disease conditions. During neurodegenerative illnesses, high concentrations of ATP are released from the damaged neuronal and non-neuronal cells of the brain; then, this ATP is ...
Peter Illes, Henning Ulrich, Jiang-Fan Chen, Yong Tang   +3 more
openaire   +3 more sources

Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases

Frontiers in Physiology, 2014
In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez, Stephani eVelasquez, Eliseo A Eugenin, Eliseo A Eugenin   +3 more
doaj   +1 more source

Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases

Frontiers in Physiology, 2022
Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue, adenosine, all have the capacity to modulate cellular signaling pathways.
Erika Y. Faraoni, Cynthia Ju, Simon C. Robson, Holger K. Eltzschig, Jennifer M. Bailey-Lundberg   +4 more
doaj   +1 more source

Purinergic and Calcium Signaling in Macrophage Function and Plasticity

Frontiers in Immunology, 2014
In addition to a fundamental role in cellular bioenergetics, the purine nucleotide adenosine triphosphate (ATP) plays a crucial role in the extracellular space as a signaling molecule.
Bimal N Desai, Norbert eLeitinger
doaj   +1 more source

Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain

Folia Neuropathologica, 2022
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec, Anna Wilkaniec, Agata Adamczyk   +2 more
doaj   +1 more source