Results 21 to 30 of about 2,691,050 (227)
Role of purinergic receptors in the Alzheimer's disease. [PDF]
Purinergic Signal, 2018 Etiology of the Alzheimer’s disease (AD) is not fully understood. Different pathological processes are considered, such as amyloid deposition, tau protein phosphorylation, oxidative stress (OS), metal ion disregulation, or chronic neuroinflammation ...
Cieślak M, Wojtczak A.
europepmc +2 more sources
Purinergic receptors in embryonic and adult neurogenesis
Neuropharmacology, 2016 ATP (adenosine 5'-triphosphate), one of the most ancient neurotransmitters, exerts essential functions in the brain, including neurotransmission and modulation of synaptic activity.
Henning Ulrich +2 more
exaly +2 more sources
Purinergic Receptors in Thrombosis and Inflammation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 Under various pathological conditions, including thrombosis and inflammation, extracellular nucleotide levels may increase because of both active release and passive leakage from damaged or dying cells. Once in the extracellular compartment, nucleotides interact with plasma membrane receptors belonging to the P2 purinergic family, which ...
B. Hechler, C. Gachet
semanticscholar +3 more sources
Cell Transplantation, 2015 Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination ...
Rosa Gómez-Villafuertes Ph.D. +5 more
doaj +2 more sources
ATP ion channel P2X purinergic receptors in inflammation response.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 Different studies have confirmed that P2X purinergic receptors play a key role in inflammation. Activation of P2X purinergic receptors can release inflammatory cytokines and participate in the progression of inflammatory diseases.
Ji-Peng Liu +6 more
semanticscholar +1 more source
Purinergic signaling in the male reproductive tract
Frontiers in Endocrinology, 2022 Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin +4 more
doaj +1 more source
Purinergic Signaling in Liver Pathophysiology
Frontiers in Endocrinology, 2021 Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
doaj +1 more source
Painful Purinergic Receptors [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2008 Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive sensitivity following tissue injury. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and ...
Diana, Donnelly-Roberts +4 more
openaire +2 more sources
Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells
Frontiers in Endocrinology, 2020 The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel +3 more
doaj +1 more source
Purinergic signaling: Diverse effects and therapeutic potential in cancer
Frontiers in Oncology, 2023 Regardless of improved biological insights and therapeutic advances, cancer is consuming multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and physiological parameters as its hallmarks.
Jasmeet Kaur, Sanchit Dora
doaj +1 more source