Purinergic signaling: Diverse effects and therapeutic potential in cancer
Frontiers in Oncology, 2023 Regardless of improved biological insights and therapeutic advances, cancer is consuming multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and physiological parameters as its hallmarks.
Jasmeet Kaur, Sanchit Dora
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Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Tasker, Paul N. +3 more
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Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications
Molecular Imaging, 2020 Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes.
Hamideh Zarrinmayeh PhD +1 more
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The Role of Purinergic Signaling in Heart Transplantation
Frontiers in Immunology, 2022 Heart transplantation remains the optimal treatment option for patients with end-stage heart disease. Growing evidence demonstrates that purinergic signals mediated by purine nucleotides and nucleosides play vital roles in heart transplantation ...
Yanzhi Jiang +3 more
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Purinergic signaling in the gastrointestinal tract [PDF]
, 2011 Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Geoffrey Burnstock, Burnstock, G
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Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone [PDF]
, 2002 Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials.
Catsicas, M. +15 more
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Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion
Viruses, 2020 Purinergic receptors are inflammatory mediators activated by extracellular nucleotides released by dying or injured cells. Several studies have described an important role for these receptors in HIV-1 entry, particularly regarding their activity on HIV-1
Tracey L. Freeman, Talia H. Swartz
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Journal of Pharmaceutical Analysis, 2023 Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen +8 more
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The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ +18 more
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P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
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