Results 21 to 30 of about 2,313,736 (322)
Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases
Frontiers in Physiology, 2014 In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez +3 more
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Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders
Frontiers in Pharmacology, 2017 Extracellular nucleosides and nucleotides, such as adenosine and adenosine triphosphate (ATP), are involved in many physiological and pathological processes in adipose tissue (AT).
Marco Tozzi, Ivana Novak
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Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy. [PDF]
Purinergic Signal, 2021 Zhang WJ.
europepmc +2 more sources
PLoS ONE, 2014 The dura mater and its vasculature have for decades been central in the hypothesis of migraine and headache pathophysiology. Although recent studies have questioned the role of the vasculature as the primary cause, dural vessel physiology is still ...
Kristian Agmund Haanes, Lars Edvinsson
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Cell Transplantation, 2015 Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination ...
Rosa Gómez-Villafuertes Ph.D. +5 more
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Purinergic receptors in cognitive disturbances
Neurobiology of Disease, 2023 Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-sensitive classes broadly interfere with cognitive processes both under quasi normal and disease conditions.
Peter Illes +3 more
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Purinergic receptors in airway hydration. [PDF]
Biochem Pharmacol, 2021 Airway epithelial purinergic receptors control key components of the mucociliary clearance (MCC), the dominant component of pulmonary host defense. In healthy airways, the periciliary liquid (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force.
Lazarowski ER, Boucher RC.
europepmc +4 more sources
Purinergic Signaling in Liver Pathophysiology
Frontiers in Endocrinology, 2021 Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
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Purinergic signaling in the male reproductive tract
Frontiers in Endocrinology, 2022 Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin +4 more
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Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
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